Protein Info for AMB_RS00205 in Magnetospirillum magneticum AMB-1

Annotation: threonine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 719 transmembrane" amino acids 171 to 192 (22 residues), see Phobius details PF00107: ADH_zinc_N" amino acids 183 to 303 (121 residues), 59.1 bits, see alignment E=6.6e-20 PF01408: GFO_IDH_MocA" amino acids 401 to 509 (109 residues), 69.5 bits, see alignment E=6.6e-23 PF02894: GFO_IDH_MocA_C" amino acids 553 to 717 (165 residues), 27.8 bits, see alignment E=3.3e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to mag:amb0040)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2WBD1 at UniProt or InterPro

Protein Sequence (719 amino acids)

>AMB_RS00205 threonine dehydrogenase (Magnetospirillum magneticum AMB-1)
MKQVIQSTRSGKLSLKQVPDPRVRAGHVLVATRASLISAGTERMVIDFARKSLAAKASAR
PDLVRKVLDKARRDGLISTFKAVMARLDEPLPLGYSAAGTISAVGAGLEGAFTTGQRVAM
AGAGLANHAELNVVPRNLVAAIPDDVTDEEAAFGTVGSIAMAGMRSLGAQLGDVVAVLGV
GLVGQLAVQLLALQGARVVALDVNPQRLALAKAMGAELTWVLGEHGLTEAVAALTGGIGC
DSVLIAAATDSSEPLALAAELARDRAKVVLVGKTGTEFDYAAYMKKELTLSVSRSYGPGR
YDEDFESRGVKYPVGWVRWTEAENLRECVRLMSPSLPRRLDVGALITHRFAFDDAESAYQ
LVTGGAEPHLGVVLGYGDHSAGRAEARVFPAAKAPAGRCVMGVIGAGNFARTVLLPELVR
LPNVEFRTLCTQRGQTAEHGQQTFGFANATTDVDLVLNDPAINAVLVATRHGNHAEMTAR
VLEAGKSVLVEKPLALDREQLNRVITARQGSPGFFTIGFNRRFAPLTLKARAHLARHPGP
KVLMLRVNAGALPAESWVNAAEEGGGRVLGELCHFMDLARTLAGSPIATVQAESAAVTHG
GCDDLSVTLTFKDGSLATIVYTAQGDTAHSKERFECFAGGTVAVIDNFLTLSITQGGRTR
TEKSLGQDKGHRAELDAFTRAVATGGPAPADEAELIETSLATIAVLESLRDGRRVSLED