Protein Info for ABZR88_RS20865 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: DNA helicase RecQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 721 transmembrane" amino acids 47 to 68 (22 residues), see Phobius details TIGR01389: ATP-dependent DNA helicase RecQ" amino acids 6 to 587 (582 residues), 778.1 bits, see alignment E=5.6e-238 TIGR00614: ATP-dependent DNA helicase, RecQ family" amino acids 7 to 454 (448 residues), 561.7 bits, see alignment E=1.3e-172 PF00270: DEAD" amino acids 20 to 178 (159 residues), 84.2 bits, see alignment E=2.7e-27 PF00271: Helicase_C" amino acids 219 to 324 (106 residues), 67.7 bits, see alignment E=3e-22 PF16124: RecQ_Zn_bind" amino acids 336 to 397 (62 residues), 62.1 bits, see alignment 2e-20 PF09382: RQC" amino acids 400 to 508 (109 residues), 118.7 bits, see alignment E=3.5e-38 PF00570: HRDC" amino acids 522 to 587 (66 residues), 71.8 bits, see alignment E=1.1e-23 PF14493: HTH_40" amino acids 623 to 710 (88 residues), 90 bits, see alignment E=2.8e-29

Best Hits

KEGG orthology group: K03654, ATP-dependent DNA helicase RecQ [EC: 3.6.4.12] (inferred from 48% identity to fjo:Fjoh_2808)

Predicted SEED Role

"ATP-dependent DNA helicase RecQ" in subsystem DNA-replication or DNA repair, bacterial RecFOR pathway

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (721 amino acids)

>ABZR88_RS20865 DNA helicase RecQ (Mucilaginibacter yixingensis YX-36 DSM 26809)
MTTPAQALQKYFGYSSFRHQQEAIVQQLLNKGDAMVLMPTGGGKSICYQLPAVLLGGLTI
VISPLIALMKDQVDALNVTGIPAAYLNSTQSSAEQSDIIQRLRSGEIKLLYLAPERLFKS
ESRLTDFLKSLSVSLIAIDEAHCISHWGHDFRPEYLMLAGLKTEFPNIPVIALTATADQL
TRKDILEKLNLHNPAQFVSSFNRANINYTVAPKKNSTGQLLDFLDKHKEDSGIIYCLSRQ
STEDLAAQLQREGFSAEAYHAGLSNDVKARNQEAFLRDEVRIMVATIAFGMGINKSNVRY
VVHMDLPRNIEGYYQETGRAGRDGLPSEALLFFSAGDAFKLQRFAQVEDNPEQTRIMLRK
LDDMVQYCQLQSCRRQYLLKYFNEDFPGHCGSCDVCLSEFEKFDGTVIAQKALSAVARLK
ERFGMGYVIDLLRGSNSAKLREEHKQLKTYGAGADISKADWQRHLRELIQLGYLQTSQDA
YPVLQLTERSDAVLKGLEKIELTLSQSTEETHQPETPPHEAPLFNQLKNQRRDLAERENV
PAYIVLSDATLMELATYLPQSLPELRQISGFGELKLQRYGEAFLNIIIPYCQANGLTSKI
AERTTKRARERKPKPKTTGASNTQQESFNLYKSGKSFEEIAKQRDLSPQTVQNHLCAFIT
TGELDISTFVSAQKLPVIADAVESYGSEYLSPLKEVLGDDYSYLEIRAVISWMKREMNQD
S