Protein Info for ABZR88_RS20335 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: adenosylhomocysteinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05221: AdoHcyase
  • amino acids 10 to 147 (138 residues), 240.8 bits, E=4.8e-75
  • amino acids 147 to 437 (291 residues), 210.6 bits, E=7.3e-66
• TIGR00936: adenosylhomocysteinase
  • amino acids 11 to 430 (420 residues), 621.5 bits, E=3.3e-191
• PF00670: AdoHcyase_NAD
  • amino acids 197 to 358 (162 residues), 258.8 bits, E=5.8e-81
• PF13241: NAD_binding_7
  • amino acids 217 to 309 (93 residues), 27.4 bits, E=1.1e-09
• PF02826: 2-Hacid_dh_C
  • amino acids 217 to 306 (90 residues), 34.1 bits, E=4.6e-12
• PF07991: IlvN
  • amino acids 218 to 283 (66 residues), 28.5 bits, E=2.8e-10

Best Hits

Swiss-Prot: 82% identical to SAHH_FLAJ1: Adenosylhomocysteinase (ahcY) from Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101)

KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 87% identity to psn:Pedsa_3593)

MetaCyc: 67% identical to Adenosylhomocysteinase (Homo sapiens)
ADENOSYLHOMOCYSTEINASE-RXN [EC: 3.13.2.1]

Predicted SEED Role

"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)

MetaCyc Pathways

• S-adenosyl-L-methionine salvage II (3/3 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
• L-methionine degradation I (to L-homocysteine) (2/3 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)

KEGG Metabolic Maps

• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.13.2.1 or 3.3.1.1

Protein Sequence (438 amino acids)

>ABZR88_RS20335 adenosylhomocysteinase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MSSVETTYTKYKVKDFSLADWGRKEIELAEAEMPGLMSLRAEYGPSKPLAGARIAGCLHM
TIQTAVLIETLIALGAEVTWSSCNIFSTQDHAAAAIAAAGISVYAWKGMNAEEFDWCIEQ
TLFFGEDRQPLNMILDDGGDLTNMVLDKYPELVAGIKGLSEETTTGVHRLYERVKNGTLP
IPAININDSVTKSKFDNKYGCRESLVDAIRRATDVMMAGKVGVVCGYGDVGKGSADSLRN
AGVRVIVTEIDPICALQAAMEGYEVKKLSTAIAEADIVVTATGNKNIVREAHFRALKDKA
IVCNIGHFDNEIDMAWLNGAYGNTKIEIKPQVDKYNVDGKDVIVLAEGRLVNLGCATGHP
SFVMSNSFTNQTLAQLELWTNGGAYENKVYTLPKHLDEKVARLHLAKIGVELEVLDQDQA
DYIGVPVEGPFKPEYYRY