Protein Info for ABZR88_RS20280 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: glucosamine-6-phosphate deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01182: Glucosamine_iso
  • amino acids 22 to 244 (223 residues), 69.1 bits, E=5.3e-23
• TIGR00502: glucosamine-6-phosphate deaminase
  • amino acids 24 to 261 (238 residues), 244.4 bits, E=6.3e-77
• PF02585: PIG-L
  • amino acids 361 to 536 (176 residues), 55.1 bits, E=1.2e-18

Best Hits

Swiss-Prot: 52% identical to Y258_BACTN: Putative glucosamine-6-phosphate deaminase-like protein BT_0258 (BT_0258) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K02564, glucosamine-6-phosphate deaminase [EC: 3.5.99.6] (inferred from 81% identity to phe:Phep_4142)

Predicted SEED Role

"Glucosamine-6-phosphate deaminase (EC 3.5.99.6)" in subsystem Chitin and N-acetylglucosamine utilization or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 3.5.99.6)

MetaCyc Pathways

• N-acetylglucosamine degradation I (2/2 steps found)
• N-acetylglucosamine degradation II (2/3 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (4/7 steps found)
• superpathway of N-acetylneuraminate degradation (14/22 steps found)
• superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (2/6 steps found)
• chitin degradation I (archaea) (2/7 steps found)
• chitin derivatives degradation (2/8 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.99.6

Use Curated BLAST to search for 3.5.99.6

Protein Sequence (639 amino acids)

>ABZR88_RS20280 glucosamine-6-phosphate deaminase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MARLNLLEETRYEKLAVTVYPNQKEAVAKVAQRIAGVIRNKQQNNQNAVLGLATGVTPIG
VYNELIRLHKEEGLSFQNVITFNLDEYYPMQPGAAQSYVRFMNEQLFDHIDINRNNIHIP
DGTLSLDAIPAFCLDYEKKITAAGGLDLQILGIGRTGHIGFNEPGSAPNSGTRLVTLDDL
TRSDAARDFGGKENVPTKAITMGIGTIFKAREIILMAWSKKKAPIIKKAVEGEISGEVPA
TYLQLSDHVEFVLDEDAASLLTRFDTPWLVKDCVWTNQLKKKAVIWLALEVGKPILKLTE
DDYNNNGMAQLAVEQGPVYNINIDIFNRIQHTITGWPGGKPNADDSQRPERREPARKRSV
IFSPHPDDDVISMGGTFIRLVDQGHEVHVAYQTSGNTAVWDDDVLRYVEFAIDFNQSIGE
DTTQLKKLYGNMRDFLEKKHPNELDTKEILTVKGFIRKTEAISGARYAGLPDSHIHFMAL
PFYETGKTQKNPVTAEDVRLTIELLQQVKPHQIFAAGDFADPHGTHIVCFNIILAALREL
KKTEAWVEDCWLWLYRGAWQEFDTYEIEMAVPLSPQEVVRKRNAIFKHQSQKDRPVFPGD
DAREFWKRAEDRNRETAQRYDQLGMAEYEAMEAFVRYQF