Protein Info for ABZR88_RS18615 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08267: Meth_synt_1
  • amino acids 3 to 318 (316 residues), 389.4 bits, E=1.6e-120
• TIGR01371: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
  • amino acids 6 to 760 (755 residues), 1094.9 bits, E=0
• PF01717: Meth_synt_2
  • amino acids 434 to 756 (323 residues), 518 bits, E=1.1e-159

Best Hits

Swiss-Prot: 62% identical to METE_CYTH3: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K00549, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC: 2.1.1.14] (inferred from 76% identity to phe:Phep_3138)

Predicted SEED Role

"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)" in subsystem Methionine Biosynthesis (EC 2.1.1.14)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• aspartate superpathway (21/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-methionine biosynthesis III (4/4 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
• S-adenosyl-L-methionine salvage II (3/3 steps found)
• L-methionine biosynthesis II (5/6 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)
• L-methionine biosynthesis I (3/5 steps found)
• seleno-amino acid biosynthesis (plants) (3/5 steps found)
• S-adenosyl-L-methionine salvage I (2/4 steps found)
• superpathway of seleno-compound metabolism (6/19 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.14

Protein Sequence (766 amino acids)

>ABZR88_RS18615 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MLTQNLGYPRIGSQRQLKKACEQYWAGNISLKELNATARKIREENWQLQVDAGMALIPCN
DFSFYDQVLDMSMLLGAIPSRYAPVLSQNKNNHETDLYFAMARGYQKDGLDIKAMEMTKW
FDTNYHYIVPEFTAKQEFRIFSEKLFGEFNAAQQFCGDAAKPVLIGPASYLLLGKEKEVG
FERIDLIKKLVPVYVEIINRLKTLGAKWVQLDEPCLVLDLSAKEKEALVYTHQAIANRVS
GIKILVATYFGALQDNTPLAVNLPVAALHIDLVRAPEQLDEMLKQLPDRLQLSLGVIDGR
NIWKNDYEKSLALINKAVAAIGAERVLIAPSCSLLHVPCDLELETELDYGTKNWLAFARQ
KLGELKDLAAIFEGDTALLAANKQSIEARRNSTQIHKPAVKERAAALTAQDAERLHTFAI
RREVQRERFNLPLFPTTTIGSFPQTDDIRKLRATFKKGELSLNAYEKAIEEATIAAIRWQ
EDVGLDVLVHGEFERNDMVEYFGERLDGFLFTKNGWVQSYGSRCVKPPVIYGDVSRPRDM
TVRWTTFAAAQTERHMKGMLTGPVTILQWSFVRDDQPRETTTNQIALAIRDEVVALEQAG
IGIIQIDEPAIREGLPLRKADWPQYLDWAVKAFRISASGVQDDTQIHTHMCYSEFNDIIA
HIAAMDADVITIETSRSQMDLLEAFAGFKYPNEIGPGVYDIHSPRIPTTQEMVDLLQKAA
QLLPAQNLWVNPDCGLKTRKWPETKAALENMIAAAQTARQLIEVEA