Protein Info for ABZR88_RS12070 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: argininosuccinate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00206: Lyase_1
  • amino acids 11 to 300 (290 residues), 160.2 bits, E=4.3e-51
• TIGR00838: argininosuccinate lyase
  • amino acids 13 to 394 (382 residues), 330.2 bits, E=1.2e-102

Best Hits

Swiss-Prot: 61% identical to ARLY_PARD8: Argininosuccinate lyase (argH) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K01755, argininosuccinate lyase [EC: 4.3.2.1] (inferred from 71% identity to psn:Pedsa_3197)

Predicted SEED Role

"Argininosuccinate lyase (EC 4.3.2.1)" in subsystem Arginine Biosynthesis extended (EC 4.3.2.1)

MetaCyc Pathways

• L-arginine biosynthesis I (via L-ornithine) (8/9 steps found)
• L-arginine biosynthesis II (acetyl cycle) (8/10 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (7/9 steps found)
• nitric oxide biosynthesis II (mammals) (2/3 steps found)
• urea cycle (3/5 steps found)
• canavanine biosynthesis (2/4 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)
• L-arginine biosynthesis IV (archaea) (4/9 steps found)
• superpathway of arginine and polyamine biosynthesis (9/17 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.2.1

Protein Sequence (444 amino acids)

>ABZR88_RS12070 argininosuccinate lyase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MSKIWQKTAGVDALVENFTVGRDREFDEQMAAFDVLGSLAHTRMLESIGLMSADDLQLVQ
QELKSIYKDIEQNGFVIEDGVEDVHSQIELLLTRRIGDAGKKIHSGRSRNDQVLVDLKLF
FRHQLQETVQQIDELFRLLIELSNKHKDVLLPGYTHLQIAMPSSFGLWFGAYAESLADDM
ELILAAYKITNKNPLGSAAGYGSSFPLNRTMTTQLLGFAALNHNVVYAQMGRGKTERIIA
QALSSVAATLARMAMDQCLYLSQNFAFVSYPENLTTGSSIMPHKKNPDVWEIMRGKCNRL
QALPNDVAMMTTNLPSGYHREMQLLKELLFPAFAELNNCLHMAKFMLEHIEVKNDILNDP
KYAYLFSVEEVNRLALEGVPFRDAYKQVGIAIEQGNFNPEKKVNHTHEGSIGNLHNAEIS
AAMNGLLSQFKFDEVATAVKELVK