Protein Info for ABZR88_RS11570 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: nicotinate phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF18127: NAMPT_N
  • amino acids 5 to 102 (98 residues), 118.1 bits, E=1.7e-38
• PF04095: NAPRTase
  • amino acids 176 to 405 (230 residues), 158.9 bits, E=1.8e-50

Best Hits

KEGG orthology group: K03462, nicotinamide phosphoribosyltransferase [EC: 2.4.2.12] (inferred from 72% identity to mtt:Ftrac_2686)

Predicted SEED Role

"Nicotinamide phosphoribosyltransferase (EC 2.4.2.12)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.4.2.12)

MetaCyc Pathways

• NAD biosynthesis from nicotinamide (2/2 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.12

Protein Sequence (473 amino acids)

>ABZR88_RS11570 nicotinate phosphoribosyltransferase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MKRENLILLADAYKYAHHKFYIPGTTNIYSYLESRGGWFDETVFFGLQYFLKEYLQGQAF
TQVDLDEADVFLKQVFGRDDVFDRSKFQYILDKYDGRLPVRIKAVPEGTVVPTSNVLMTI
ENTDPECYWLTNFLETLLMQVWYPCTVATLSHEVRKTVTRFYNETATEGAEAGIDFVLND
FGFRGVSSVESAKLGGAAHLLNFSGSDTLAGSGMAIKYYAAEKVYGQSIPATEHSICTLL
GEEGELEVFKHVLRSFPTGVVACVSDSYNIFRACEEYWGTELRDEILNRQGTLVIRPDSG
DPVMTLLRIFEILFDKFGYTVNSKGYKVLPPQIRVIQGDGVNYKEIITIYNALKDHGISA
ENLVLGMGGALLQKVDRDTQKFALKCSSAIINGQEVNVEKRPTEMDAQGNISGSFKKSKG
GRLKLVKTNGTFKTINQNEPDNLPDQLHIVFENGQLVNPVTFEQIKANIKASN