Protein Info for ABZR88_RS09070 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: type I polyketide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 22 to 366 (345 residues), 202.3 bits, E=5.7e-63
• TIGR01733: amino acid adenylation domain
  • amino acids 43 to 441 (399 residues), 368.3 bits, E=2.2e-114
• PF13193: AMP-binding_C
  • amino acids 425 to 499 (75 residues), 39.6 bits, see alignment (E = 4e-13)
• PF00550: PP-binding
  • amino acids 529 to 592 (64 residues), 56.4 bits, see alignment (E = 1.5e-18)
  • amino acids 1518 to 1584 (67 residues), 53 bits, see alignment (E = 1.7e-17)
• PF00109: ketoacyl-synt
  • amino acids 612 to 860 (249 residues), 224 bits, E=1.2e-69
• PF02801: Ketoacyl-synt_C
  • amino acids 868 to 983 (116 residues), 136.8 bits, 1.8e-43
• PF16197: KAsynt_C_assoc
  • amino acids 989 to 1098 (110 residues), 55.4 bits, 3.9e-18
• PF22621: CurL-like_PKS_C
  • amino acids 1049 to 1109 (61 residues), 46.4 bits, see alignment (E = 1.5e-15)
• PF22336: RhiE-like_linker
  • amino acids 1054 to 1110 (57 residues), 36.6 bits, see alignment (E = 1.8e-12)
• PF00698: Acyl_transf_1
  • amino acids 1130 to 1404 (275 residues), 183.2 bits, E=4.4e-57
• PF00202: Aminotran_3
  • amino acids 1743 to 2083 (341 residues), 154.4 bits, E=1.9e-48

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (39/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
• fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
• mycobactin biosynthesis (1/11 steps found)
• pederin biosynthesis (2/14 steps found)
• bryostatin biosynthesis (2/19 steps found)
• mupirocin biosynthesis (1/26 steps found)
• corallopyronin A biosynthesis (2/30 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Protein Sequence (2193 amino acids)

>ABZR88_RS09070 type I polyketide synthase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MNYFSDTSDRQSSIVLNLYQQFEHQAQAVPDAIAVAHGDVMITYRELNDLSDALAIEINN
AAVTSNILGVSASRGVYTIVSLLAILKSGKAYLPLDPSYPAERLRQIIAESGITHCIARS
VENALFTDLGLRAINSDEKYPQATPLKIALENPLTYVLFTSGSTGKPKGVCMAGNALVNL
LQWQQRYSASAPGFKTLQYAPLTFDVSFQEIFATLTTGGTLVLVDDETRLDPQRLLHYTD
EQQINRIFLPFVALQYLTAAADDLLPRSLQEVMTAGEQLKITEQIVAFFKALRGCKLFNQ
YGPTESHVVTQLELTGDPELWPALPDIGVAIDHTEILILDEELKPVANGTQGELCISGVC
LAQGYLNRPDLTAEKFIGYTSPQGQTKRIYRTGDLARVMENGNIEYLGRIDNQVKIRGNR
VEPGEIEVVINKLDFVKQAVVVAREYGGGQKRLIAYLVAMGAEQNTQAVKKQAADNLPDY
MVPSAFIWLDEFPQTSSGKVDRKALPAPIINRPELNTLYQAPSNQTQKRLAGLWADLLQY
DKIGIHDNFFDLGGNSLLAINTVSALRSQFGYTVPVTRVYQSPTVAGIAAYIDGEQQQLV
LPTQRKKNDAGDIAIIAMAGRFPGARNVAEFWELLKQGKEGVSFFTDAELDENIPDSLKN
NSLYVKARGVLDTPGALDTAFFNLAPRMAELMDPQQRLFMEIAWEVLETAGYPPAQYGDG
IGVWAGSANNSYYYNNILTNPEAVEQAGAFQVMTMNEKDYIATRTAYELNLKGPAVSVYS
ACSTSLLAVSQAVDALRNGYCKMALAGGVTITSPVKSGHLYNEGAMLSRDGHTRTFDSSA
TGTVFSDSAGIVLLKPLEDALNDGDTIYALIKGTGVNNDGSGKGSFTAPNAAGQAGAIAS
AIQDADISASDISYIEAHGTATPLGDPIELEGLKLAFGKQSKNQYCAIGSVKSNMGHMIA
ASGVAGLIKTALCLHHKVLVPSLFYNEANPAINFIDSPFKVNTQLRDWESTGKRNAGVSS
FGVGGTNVHVVLQDFEQDTISAVSERPYQLLTWSAKSEYSRDAYAEALKTLDDQDNLADV
AYTLQIGRTEFNRRRFVVAANHIDLKARLATPVSPLLVNTLKEKATEVAFMFPGQGAQYV
GMGADLYLHEPVFKNAIDECAELIKQYAGYDIREVIYPTDSKGDKLSNLTQTYYIQPAIF
TIEYALAQLWQSWGVQPAALLGHSIGEFVAAHLAGVFSLEDALKMITARAKLIQDLPEGK
MLALRVPYQDIEKLLPEGLSIGVINAHNLTVVSGGPALITTFADALAEQNIPSRVLNVSH
ALHSPMMEAAIEPFKKVVLTVKLQTPRLPILSGVSGNWMTDAQATSADYWARHMRETVNF
AATLKTLTEDNDKRILLEVGPGNVTATLAKNQADVKPNLVTVAGLDQQAASAYIPVLNAL
GRLWLHGINIDWNKFYYKQGRRKIAAPTYVFDRKNYWIKPGKVAQTTPTLPTPIPALAQT
QESPVQHIIMREIVLANKIREIFEGASGIPMSQIPVDMSFAEAGFDSLLLTQIAMNLKKE
FGVQITFRKLYEEYSTVSLLAQFLDESLPADKFQPIHSNGKPAVAPALTQLPVSGNGSSH
LDLITQQLNLLAQQVALLQNSNGTLQTQVNGVAHHVPMQVTPQPSPNGITAEEMVEIKKP
FGATARIDRQTTDLTDDKQDYLNNLTKRYNAKTGKSKAYTQQHRNGMADPRVVSGFRPAT
KEMVYPLVVNRSKGSHVWDLDGNDYIDALNGFGSNFLGYNMDFLKEAFQKQLEAGYEIGP
QHELAGEVCQLINEFTGFERSALCNTGSEAVLGAMRMSRTVTGRSLIVAFAGSYHGINDE
VLVRGTKVLKTVPAAPGIMPEVVQNMLILDYGTDESLEIIRQRAHELAAVLVEPVQSRRP
EFQPVAFLKELRTITKASGTALIFDEVITGFRMHPGGAQAIFDIRADIGTYGKVIGGGMP
IGVIAGVPEFMDALDGGTWQYGDGSVPEAGVTYFAGTFVRHPLALAGAKACLDYLKLKGL
ALQQGVNAKVKRLADALNATCIKYHLPLYIANFGSLWKIKFKYELAYGELLFTLMRYRNI
HIWDIFPCFLTEAHTDAEIDAIINAFNESVEELMVAGFLPSETPEPEASDKLDPFNSPPE
PGARLGRDEDGHPAWFVPNPDVPGKYLQIETKP