Protein Info for ABZR88_RS09010 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: DNA topoisomerase III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 TIGR01056: DNA topoisomerase III" amino acids 1 to 591 (591 residues), 520.9 bits, see alignment E=3e-160 PF01751: Toprim" amino acids 3 to 138 (136 residues), 46 bits, see alignment E=5e-16 PF01131: Topoisom_bac" amino acids 158 to 570 (413 residues), 385.8 bits, see alignment E=2.7e-119

Best Hits

KEGG orthology group: K03169, DNA topoisomerase III [EC: 5.99.1.2] (inferred from 74% identity to phe:Phep_2044)

Predicted SEED Role

"DNA topoisomerase III (EC 5.99.1.2)" in subsystem DNA topoisomerases, Type I, ATP-independent (EC 5.99.1.2)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.2

Use Curated BLAST to search for 5.99.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (602 amino acids)

>ABZR88_RS09010 DNA topoisomerase III (Mucilaginibacter yixingensis YX-36 DSM 26809)
MKVIIAEKPSVGREIARVFGANTKREGYIEGKGYTFTWAFGHLLQLAAPQEYGYYGWSVQ
NLPMLPPKFKLSIRKVRTKEGLVDDPGVKKQLDIIKALFDEATEIIVATDAGREGELIFR
YIYYYLKCKKPFKRLWISSQTDAAIKDGFRNLKPGSDYDTLFNSAHCRSQSDWLVGMNAT
QALSLASGNKGVLSLGRVQTPTLAMICARYLENRDFKPETYFQVAIFPDKDGQSFKAIAD
KNFKTREEAQAVFDGVGPTGNIASVEAKPRKEPPPLLHDLSSIQQEANKKKGFTADQTLG
ILQNLYEGKLVTYPRTGSRYIGDDVFAQVPGLIAGLTEHSDFGKQATVLADAKLSKRSVN
AKKVTDHHAILPTGEKPWQLSPDQQAIYDLVAGRMLEAFHGDCIKEITKITITSGHKFIA
SGTVIRTAGWRAVFNDPEDDKKDEDNAALPKVTQGEDLPIKEKTILEKQTKPKALYNEAT
LLKALETAGKEIEDEELREAMKAGGLGTPATRAAIIETLLTRNYILREKKNLVPTPTGLA
VYQVVKDRRIAQAELTGSWEKRLEEIRSGASVNEFQEEIKAYTREITQELLRSGKAVVLQ
PA