Protein Info for ABIE41_RS23880 in Bosea sp. OAE506

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 30 to 142 (113 residues), 132 bits, E=1.9e-42
• PF02770: Acyl-CoA_dh_M
  • amino acids 146 to 239 (94 residues), 79.8 bits, E=2e-26
• PF00441: Acyl-CoA_dh_1
  • amino acids 253 to 398 (146 residues), 90.1 bits, E=2.5e-29

Best Hits

Swiss-Prot: 67% identical to GCDH_CAEEL: Probable glutaryl-CoA dehydrogenase, mitochondrial (F54D5.7) from Caenorhabditis elegans

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 88% identity to rpx:Rpdx1_1261)

MetaCyc: 71% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (5/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Protein Sequence (405 amino acids)

>ABIE41_RS23880 acyl-CoA dehydrogenase (Bosea sp. OAE506)
MAEAARSHSTSHKLAEFTWDDAFLLDEQLTEDERLIRDTARDFAQEKLQPRISEAYLDEK
TDRSIFNEMGELGLLGVTVPEEYGCAGANYVSYGLVAREVERVDSGYRSMMSVQSSLVMY
PIYAYGDETQRKKYLPKLGSGEWVGCFGLTEPDAGSDPAGMKTRAEKVADGYRLTGSKMW
ISNSPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVI
VPEENLLPNVSGLKGPFGCLNRARYGISWGVMGAAEDCFHRARQYGLDRKQFNKPLAQTQ
LFQKKLADMLTEISLGLQGSLRVGRLMDEGKMAPEMISLVKRNNCGKALDIARQSRDMHG
GNGISIEYHVMRHAANLETVNTYEGTHDVHALILGRAVTGLQAFF