Protein Info for ABIE41_RS23235 in Bosea sp. OAE506

Annotation: DNA mismatch repair endonuclease MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 601 TIGR00585: DNA mismatch repair protein MutL" amino acids 2 to 309 (308 residues), 276.7 bits, see alignment E=1.7e-86 PF02518: HATPase_c" amino acids 22 to 77 (56 residues), 30 bits, see alignment 1.2e-10 PF13589: HATPase_c_3" amino acids 24 to 118 (95 residues), 38.3 bits, see alignment E=2.7e-13 PF01119: DNA_mis_repair" amino acids 214 to 328 (115 residues), 112.7 bits, see alignment E=1.7e-36 PF08676: MutL_C" amino acids 417 to 558 (142 residues), 166.4 bits, see alignment E=6.5e-53

Best Hits

Swiss-Prot: 60% identical to MUTL_METSB: DNA mismatch repair protein MutL (mutL) from Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 60% identity to msl:Msil_2869)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (601 amino acids)

>ABIE41_RS23235 DNA mismatch repair endonuclease MutL (Bosea sp. OAE506)
MPVRRLDPVLVDRIAAGEVIERPAAAVKELVENAIDAGARAIAVTIAAGGRELIRVVDDG
AGMTPEDLALAVERHATSKLPDGDLFAIQSLGFRGEALPSIGSVARLSIATRRHDATQGS
GLVVEAGEKGVVRPVAAAPGTRIEVSDLFAFTPARLKFLKSDRAEAQAVSEMLRRLAIAR
PAIRFSLEGEHVSPFDWPAEGLGEEGQLRRLGRALGRDFPENALRLDAAREGVHVTGFAG
LPTFHRGTSAGVHLAVNGRPVRDKLLLSAVRGAYADVVPSDRHPVLFLDVACDPRAVDVN
VHPAKSEVRFRDPQLVRGLVVSGLKAALAEAGHRATTTGGARTLEAFRAVFAGTGNSTSP
LRPTLPDTPAWNAPATGFDARPQQGFAGFDASSADARAHLAEASPDALDRPLGAARAQLH
ETYIVAQTREGVVIVDQHAAHERLVYERLKAERARSGIATQPLLLPEVVELDPVDADRLN
AASEDLATLGLRLEPFGPGAVLVREAPQQLAGGNLQKLVRDVADALAEHGTAGSLERRLD
HVLATMACHNSVRAGRRLRPEEMDALLREMEITPNSGQCNHGRPTYVELKLADIERLFGR
R