Protein Info for ABIE41_RS22955 in Bosea sp. OAE506
Annotation: heme o synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 67% identical to COXX_METNO: Protoheme IX farnesyltransferase (ctaB) from Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
KEGG orthology group: K02301, protoheme IX farnesyltransferase [EC: 2.5.1.-] (inferred from 67% identity to mno:Mnod_0262)Predicted SEED Role
"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)
MetaCyc Pathways
- aerobic respiration I (cytochrome c) (3/4 steps found)
- arsenite to oxygen electron transfer (1/2 steps found)
- aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)
- arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
- Fe(II) oxidation (2/6 steps found)
KEGG Metabolic Maps
- Biosynthesis of terpenoids and steroids
- Carotenoid biosynthesis - General
- Methionine metabolism
- Oxidative phosphorylation
- Porphyrin and chlorophyll metabolism
- Riboflavin metabolism
- Terpenoid biosynthesis
- Tryptophan metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 1.9.3.1, 2.5.1.-
Use Curated BLAST to search for 1.9.3.1 or 2.5.1.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (315 amino acids)
>ABIE41_RS22955 heme o synthase (Bosea sp. OAE506) MSAAFETRTDGVALTSTGEARDFFALLKPRVMSLVVITAMAGMATAPGTVHPVIAFASLL AIAVGAGASGCLNMWYDADIDQLMSRTAKRPIPSGRVLPSEALAFGLTLSIGSVLVLGLV ANLLAAAMLAFTIFFYAVVYSMWLKRWTPQNIVIGGAAGAFPPMIGEAVVTGDLGIHSIV LFAIIFLWTPPHFWALALVKAADYGRAGIPMMPNAAGPAATRRQIVLYTLLMAPVAVLPA LMGFAGLAYLVISAASGLAMIVLSIRVWRTTEGEAATKACWSLFGFSILYLFGLFAVLLV ENGLGLMWALPKVIG