Protein Info for ABIE41_RS20690 in Bosea sp. OAE506

Annotation: alpha/beta fold hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00561: Abhydrolase_1
  • amino acids 156 to 384 (229 residues), 64.3 bits, E=1.4e-21
• PF12146: Hydrolase_4
  • amino acids 157 to 383 (227 residues), 32.2 bits, E=7e-12

Best Hits

KEGG orthology group: None (inferred from 58% identity to rec:RHECIAT_PB0000131)

Predicted SEED Role

"N-formylglutamate deformylase (EC 3.5.1.68)" in subsystem Histidine Degradation (EC 3.5.1.68)

MetaCyc Pathways

• L-histidine degradation II (5/5 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Histidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.68

Use Curated BLAST to search for 3.5.1.68

Protein Sequence (404 amino acids)

>ABIE41_RS20690 alpha/beta fold hydrolase (Bosea sp. OAE506)
MGLRARIAAAARDAELRRFGSGLVAVLQIEGAGDDILLRLDDGVVVFEGTAAPDIVLSAA
DADWARFLTLPPPPRFQAFTALAIANPAFTLSGDPLVIAQARAVIERLIELVVLSPAAPA
PSVARRMSQIEGRYHRVALPEGAAEIYVESAGSGRPVLFLHTAGADSRQFHGQLADVALA
TNWRLIAPDMPFHGRSMPPEGWLGEPYRLSGARYLGWCAAIIEQVIGEKAIVAGGSMGAA
LALLLAAERPDLVAGVIAIEPPFRSKGRRNPYQHHVGVHAGLHNAAFVRGLMSPTSPIDS
RRRAAWIYSQGAPEIYAGDLAFYSDEFDGAEVAPRIDAARTPVSLLCGTYDYSATPEDGA
KLASLIPGADLRVMEGLGHFPMCEDADLFRPHLLAALAHVGGPR