Protein Info for ABIE41_RS17870 in Bosea sp. OAE506

Annotation: biotin--[acetyl-CoA-carboxylase] ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00121: biotin--[acetyl-CoA-carboxylase] ligase
  • amino acids 14 to 245 (232 residues), 121.8 bits, E=1.7e-39
• PF03099: BPL_LplA_LipB
  • amino acids 36 to 142 (107 residues), 54 bits, E=1.7e-18
• PF02237: BPL_C
  • amino acids 203 to 249 (47 residues), 32.8 bits, 5.4e-12

Best Hits

KEGG orthology group: K03524, BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC: 6.3.4.15] (inferred from 48% identity to msl:Msil_2932)

Predicted SEED Role

"Biotin--protein ligase (EC 6.3.4.9, EC 6.3.4.10, EC 6.3.4.11, EC 6.3.4.15)"

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (4/4 steps found)

KEGG Metabolic Maps

• Biotin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.15

Protein Sequence (258 amino acids)

>ABIE41_RS17870 biotin--[acetyl-CoA-carboxylase] ligase (Bosea sp. OAE506)
MLPEAARAAGYRLIIRDEVGSTMEEARRALHQGDPGLLWIVARSQNAGRGRHGRQWTSPP
GNLYASLLLVNPCEPALAPQLGFVAGLALHDAAARVTGLAAPRLALKWPNDLLVDGAKCS
GLLLEGESGAGRFAVIAGLGINIASCAQGTPYPASFLRAHAPDVTIEATLAALAEAFAER
FAIWRQAGGFGPIRQAWLVRAAFLGETITIRPPAGAVTGIFAGLDPGGRLLLETSAATQA
FDAGDLFFGAAAPEETTR