Protein Info for ABIE41_RS17600 in Bosea sp. OAE506

Annotation: UMP kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02075: UMP kinase
  • amino acids 4 to 233 (230 residues), 285.1 bits, E=2.1e-89
• PF00696: AA_kinase
  • amino acids 5 to 213 (209 residues), 132.5 bits, E=1e-42

Best Hits

Swiss-Prot: 60% identical to PYRH_AZOC5: Uridylate kinase (pyrH) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: K09903, uridylate kinase [EC: 2.7.4.22] (inferred from 67% identity to msl:Msil_3831)

MetaCyc: 48% identical to UMP kinase (Escherichia coli K-12 substr. MG1655)
Cytidylate kinase. [EC: 2.7.4.14, 2.7.4.22]

Predicted SEED Role

"Uridine monophosphate kinase (EC 2.7.4.22)" (EC 2.7.4.22)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (41/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• CMP phosphorylation (2/2 steps found)
• superpathway of pyrimidine ribonucleosides salvage (7/10 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (6/9 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.14

Use Curated BLAST to search for 2.7.4.14 or 2.7.4.22

Protein Sequence (235 amino acids)

>ABIE41_RS17600 UMP kinase (Bosea sp. OAE506)
MRPQRVLVKLSGEALAGQAGSGLDGATLTALAADIAHASREGVEIAIVVGGGNFFRGVQG
LTKGLDRTSADSIGMLGTVMNALALEHAIESAGAPARAMSAVPMPSLCESYARKRALDHL
TNGKVVVLGGGTGNPYFTTDTGAALRAAELGCSHLLKATQVDGVYSADPKKDPAATRYDT
LTHAEAISRDLKVMDTAAFALARDAGLTIVVFSIAESGMLAAVLRGEGRATYVTP