Protein Info for ABIE41_RS17440 in Bosea sp. OAE506

Annotation: transcriptional repressor LexA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 246 PF01726: LexA_DNA_bind" amino acids 2 to 63 (62 residues), 58.2 bits, see alignment E=5.8e-20 TIGR00498: repressor LexA" amino acids 105 to 245 (141 residues), 126.2 bits, see alignment E=6.5e-41 PF00717: Peptidase_S24" amino acids 125 to 240 (116 residues), 109.9 bits, see alignment E=6.2e-36

Best Hits

Swiss-Prot: 73% identical to LEXA_METNO: LexA repressor (lexA) from Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)

KEGG orthology group: K01356, repressor LexA [EC: 3.4.21.88] (inferred from 73% identity to mno:Mnod_7466)

Predicted SEED Role

"SOS-response repressor and protease LexA (EC 3.4.21.88)" in subsystem DNA repair, bacterial (EC 3.4.21.88)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.88

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (246 amino acids)

>ABIE41_RS17440 transcriptional repressor LexA (Bosea sp. OAE506)
MLTRKQFELLRFIQERLRESGVPPSFDEMKDALDLKSKSGIHRLIMALEERGFIRRLPNR
ARALEVIKLPDGAGGGLQPGARRFNPSIVQGGLGKETPPAKDGLPGRVRPVETASEDARN
TIAIPVMGRIAAGTPISAIQSRSHSVALPADMLGSGEHFALEVRGDSMVEAGILDGDTVV
IRRQDTANTGDIIVALIDDEEATLKRLRKRGSSIALEAANPAYETRVLGPDRVKIQGRLV
NLMRRY