Protein Info for ABIE41_RS17270 in Bosea sp. OAE506

Annotation: bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 774 PF01494: FAD_binding_3" amino acids 3 to 319 (317 residues), 33.1 bits, see alignment E=3.9e-12 PF00724: Oxidored_FMN" amino acids 396 to 725 (330 residues), 222.2 bits, see alignment E=1.2e-69

Best Hits

KEGG orthology group: K09461, anthraniloyl-CoA monooxygenase [EC: 1.14.13.40] (inferred from 54% identity to reh:H16_A2461)

MetaCyc: 52% identical to 2-aminobenzoyl-CoA monooxygenase/reductase subunit (Aromatoleum evansii)
Anthraniloyl-CoA monooxygenase. [EC: 1.14.13.40]

Predicted SEED Role

"Anthraniloyl-CoA monooxygenase (EC 1.14.13.40)" (EC 1.14.13.40)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.13.40

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (774 amino acids)

>ABIE41_RS17270 bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase (Bosea sp. OAE506)
MRIAVVGGGPAGLYFALLMKRDWPDLEITVFERNQPDDTFGFGVVFSDQTLDIFKAADEA
SYAAIRDNFAYWDDIEVHFKDSVHRVSGNGFCGCSRRSLLLLVQARARQLGVELRFGEEA
ADIETLKANYDLVVASDGINSRIREGWRDRFQPEVDLRPNHFTWMGSTRPFDAFTFFFKE
TPHGVFIAHCYQYEAGRSTWVLETDPETFQKAGLGAMDEAESAAFLEGVFAEELQGHKLI
TNRSLWRNFPMIRCRNWVVENVVLIGDAKATAHFSIGSGTKLAMEDAIGLHKAFHKAGLK
VDDALALYERSRREEVEKTQHAADVSLVWFEQLGRFWDFDPLRFAFGLMTRSKAITYDNL
ALRAPAMVAAVDEMVAGQLGPLARRRKDGSAVPPAFQPLKLRDVTLENRLVLAPMCQYSA
EDGVPGDWHLMHYGSRAIGGPGLIFTEMTCVSADARITPGCAGLYTDAQEAAWTRIVGFV
HANSAAKLCLQLGHAGRKGATKLMWEGMDRPLAEGAWPIISASALPYYPESQVPREMTRA
DMDRVKAEFVAAAERGARAGFDMLELHCAHGYLLASFLSPLTNRRGDEYGGSIENRLRYP
LEVFRALREIWPREKPMSVRISATDWAQGGLSAEDAVAIAEAFGAEGCDLVDVSTGQTVR
ESRPVYGRMFQTPFSDQIRNEARVATMCVGNITTADQANTIVASGRADLVALGRPHLSDP
SFVLRSAAWYGVDLMQPVQYGPGKDQLLRNTPRERQDLEALKLKAKPTRHALSP