Protein Info for ABIE41_RS10975 in Bosea sp. OAE506

Annotation: protein-glutamate O-methyltransferase CheR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 294 transmembrane" amino acids 240 to 257 (18 residues), see Phobius details PF03705: CheR_N" amino acids 5 to 53 (49 residues), 39.6 bits, see alignment 5.2e-14 PF01739: CheR" amino acids 71 to 250 (180 residues), 199.4 bits, see alignment E=6.5e-63

Best Hits

Swiss-Prot: 42% identical to CHER1_PSEAE: Chemotaxis protein methyltransferase 1 (cheR1) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00575, chemotaxis protein methyltransferase CheR [EC: 2.1.1.80] (inferred from 63% identity to met:M446_4834)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (294 amino acids)

>ABIE41_RS10975 protein-glutamate O-methyltransferase CheR (Bosea sp. OAE506)
MTESDFAFLRQLLLQRSGLALSPDKRYLAESRLGILCRRRGIADLAALVQSLRFGTDPAL
EHAVVEAMTTNETLFFRDHTPFELFRDVILPERLQTNAASRSLRIWCAAVSTGQEAYSIA
MILDEMAPRLAGWKIQIVGTDISGEVLERARKGIYSQFEIQRGLPIQMLLKHFHQEGDKW
RISERLRDMVELRQHNLLESSSHLGQFDVIFCRNVLIYFDVPTKAKVLDGMAPRLVPQGA
MLLGAAETVIGISTLIVPDRQHRGIYRSQGSIHAQPAGLGLPLEPVRATAGLRY