Protein Info for ABIE41_RS10295 in Bosea sp. OAE506

Annotation: cyclopropane-fatty-acyl-phospholipid synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 341 transmembrane" amino acids 316 to 327 (12 residues), see Phobius details PF02353: CMAS" amino acids 62 to 296 (235 residues), 135.3 bits, see alignment E=9.3e-43 PF05175: MTS" amino acids 107 to 218 (112 residues), 38.7 bits, see alignment E=2.9e-13 PF13489: Methyltransf_23" amino acids 108 to 231 (124 residues), 52 bits, see alignment E=2.4e-17 PF13847: Methyltransf_31" amino acids 115 to 219 (105 residues), 40 bits, see alignment E=1.2e-13 PF13649: Methyltransf_25" amino acids 120 to 214 (95 residues), 51.9 bits, see alignment E=3.7e-17 PF08241: Methyltransf_11" amino acids 121 to 218 (98 residues), 42.8 bits, see alignment E=2.4e-14 PF08242: Methyltransf_12" amino acids 121 to 216 (96 residues), 48.1 bits, see alignment E=5.7e-16

Best Hits

KEGG orthology group: K00574, cyclopropane-fatty-acyl-phospholipid synthase [EC: 2.1.1.79] (inferred from 64% identity to amv:ACMV_31390)

MetaCyc: 44% identical to phenylalkylamine N-methyltransferase (Ephedra sinica)
2.1.1.M76 [EC: 2.1.1.M76]; 2.1.1.M76 [EC: 2.1.1.M76]; 2.1.1.M76 [EC: 2.1.1.M76]; 2.1.1.M76 [EC: 2.1.1.M76]; 2.1.1.M76 [EC: 2.1.1.M76]

Predicted SEED Role

"Cyclopropane-fatty-acyl-phospholipid synthase-like protein, clusters with FIG005069"

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.79

Use Curated BLAST to search for 2.1.1.79 or 2.1.1.M76

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (341 amino acids)

>ABIE41_RS10295 cyclopropane-fatty-acyl-phospholipid synthase family protein (Bosea sp. OAE506)
MTILDHLGNWGERLPLPDFVTRAGIATLVGRTDRKLQQGDALPDSDFVASMGNYPIAQHA
DAANEQHYEVPAAFFQAVLGARRKYSSCFYETAQTTLDEAEVRALELTLEHADLQDGQRI
LELGCGWGSLSLFMAEKLPSAEILAVSNSASQRAFIEGEIAARGLSNLRVVTADMNAFST
LGGFDRIVSVEMFEHMANWTELLSRARGWLKPEGRLFLHVFTHRSACYRFDVEDKSDWIA
QHFFTGGLMPSRRLVHGFPELFDVESEWHWSGEHYQRTAEDWLVNFDRNLPVIDPILSQV
YGADAALWRRRWRLFFLATSGLFGYAGGDSWGVGHYRLKPA