Protein Info for ABIE41_RS09150 in Bosea sp. OAE506

Annotation: 5-dehydro-2-deoxygluconokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 644 TIGR04382: 5-dehydro-2-deoxygluconokinase" amino acids 12 to 336 (325 residues), 378 bits, see alignment E=1.8e-117 PF00294: PfkB" amino acids 13 to 325 (313 residues), 149 bits, see alignment E=2e-47 PF09863: DUF2090" amino acids 331 to 637 (307 residues), 403.1 bits, see alignment E=7.4e-125

Best Hits

KEGG orthology group: K03338, 5-dehydro-2-deoxygluconokinase [EC: 2.7.1.92] (inferred from 78% identity to mlo:mll4982)

MetaCyc: 52% identical to bifunctional 5-dehydro-2-deoxygluconokinase/5-dehydro-2-deoxyphosphogluconate aldolase (Caulobacter vibrioides NA1000)
5-dehydro-2-deoxyphosphogluconate aldolase. [EC: 4.1.2.29]; 5-dehydro-2-deoxygluconokinase. [EC: 4.1.2.29, 2.7.1.92]

Predicted SEED Role

"5-keto-2-deoxygluconokinase (EC 2.7.1.92) / uncharacterized domain" in subsystem Inositol catabolism (EC 2.7.1.92)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.92 or 4.1.2.29

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (644 amino acids)

>ABIE41_RS09150 5-dehydro-2-deoxygluconokinase (Bosea sp. OAE506)
MAASQGGPAPSLDVITIGRASVDLYGQQIGSRLEDVGSFAKSVGGCPANIAIGTSRLGLR
SALLTRVGDEQFGRFLREQLAREGVTLDGLKTDPTRLTALAILSVESDKSFPLLFYRENC
ADMALEEEDVDAAFLATARGVVVTGTHFARPNTEAAQRKAMRLMRAQGGKVILDIDYRPN
LWGLAGHAAGDNRYIASAAVSERMKSVLPGCDLVVGTEEEVLIASGESELLPALKTIRAL
TPATIVLKRGPMGCIVYEGEISDDLEDGIIGKGFPIEVYNVLGAGDAFMSGFLRGWLGGE
TLQTAATWANACGAFAVSRLLCSPESPTFAELQYFLKNGSPHRALRKDEAINHIHWATTR
RRDIPSLMALACDHRAQLEEVAQKVSADPARIRDFKVLAVRAAARVAAGRPGYGMLLDEK
HGREAMFEFARHPFSWLGRPVELPGSRPLRFETSQDIGSLLPEWPVDHCIKALCFYHPDD
EPALKQAQQEKLRGLFEAARKVGRELLVEIIASKHGPLGPDTIARAMQELYDLGIKPDWW
KLEPQASPAAWAAIEQTIARSDPWCRGVLLLGLDAPAEELEAGFAATAATPIVKGFAVGR
TIFMAAAEAWLDGRIDDEAAIADMARRFGALTELWLATRDRKAA