Protein Info for ABIE41_RS08980 in Bosea sp. OAE506

Annotation: 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 PF00364: Biotin_lipoyl" amino acids 4 to 76 (73 residues), 75.6 bits, see alignment E=3.4e-25 TIGR01347: dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex" amino acids 4 to 428 (425 residues), 576.1 bits, see alignment E=2.3e-177 PF02817: E3_binding" amino acids 137 to 167 (31 residues), 41.3 bits, see alignment (E = 2.2e-14) PF00198: 2-oxoacid_dh" amino acids 199 to 426 (228 residues), 291.4 bits, see alignment E=7.4e-91

Best Hits

KEGG orthology group: K00658, 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC: 2.3.1.61] (inferred from 74% identity to rpt:Rpal_0183)

Predicted SEED Role

"Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61)" in subsystem TCA Cycle (EC 2.3.1.61)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (429 amino acids)

>ABIE41_RS08980 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase (Bosea sp. OAE506)
MATEIRVPTLGESVSEATIGKWFKKPGDAVKADEPLVELETDKVTLEVNAPAAGVLGEIV
AKEGDTVGVSALLGMISAGGAAAAPAAKAEEKKADAAVAQASGKAGETTTAAAEAKAGEV
AGDSEIKPATKAGDSGPAVSRLAAESGVDPSKVNASGKDGRVTKGDMLAAIATGPAVAAP
APAAPVQVRAPSPVDDASREERVKMTKLRQTIARRLKEAQSNAAMLTTFNEVDMSAVMAL
RNQYKDVFEKKHGVKLGFMGFFVKACVQALKEIPAVNAEIDGTDIIYKNYYHIGVAVGTE
KGLVVPVVRDADQLSIAGVEKKIGEFGKKARDGQLKIEEMQGGTFTISNGGVYGSLMSTP
ILNAPQSAILGMHKIQERPVVVGGQVVVRPMMYLAVSYDHRIIDGKEAVTFLVRIKEGLE
DPARLVLDL