Protein Info for ABIE41_RS06710 in Bosea sp. OAE506

Annotation: FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 574 transmembrane" amino acids 47 to 61 (15 residues), see Phobius details PF00027: cNMP_binding" amino acids 39 to 124 (86 residues), 54.6 bits, see alignment E=4.1e-18 PF07992: Pyr_redox_2" amino acids 238 to 534 (297 residues), 121.5 bits, see alignment E=2.1e-38 PF00890: FAD_binding_2" amino acids 239 to 277 (39 residues), 20.6 bits, see alignment 1e-07 PF13450: NAD_binding_8" amino acids 242 to 283 (42 residues), 26.4 bits, see alignment 3.1e-09 PF13738: Pyr_redox_3" amino acids 335 to 517 (183 residues), 41 bits, see alignment E=6.4e-14 PF00070: Pyr_redox" amino acids 385 to 458 (74 residues), 27.2 bits, see alignment E=2e-09

Best Hits

KEGG orthology group: K00384, thioredoxin reductase (NADPH) [EC: 1.8.1.9] (inferred from 60% identity to bbt:BBta_0894)

Predicted SEED Role

"Thioredoxin reductase (EC 1.8.1.9)" in subsystem Glycine reductase, sarcosine reductase and betaine reductase or Thioredoxin-disulfide reductase or Wyeosine-MimG Biosynthesis (EC 1.8.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.9

Use Curated BLAST to search for 1.8.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (574 amino acids)

>ABIE41_RS06710 FAD-dependent oxidoreductase (Bosea sp. OAE506)
MTAGGAMTESPRPGAQRHDQMFPILSESEIARVAGFGMRRRYAAGVALFRTGEVGIGLLV
LVSGRVAIARHDATGRGVPVADHGPGSIIGETAGLSGKPALVDGVAVEDSEAIVLDPADL
RALLVADAMLGERITRALILRRVELIASGAGGPLLIAPADHPGRVALANFLSRNGLPFRA
LDPDIDQDARDLLTTIHPVVADYPLALLADGTVLRAPSERALAQALGMIGQADPSRIYDV
AIVGAGPAGLAASVYAASEGLSVVVLDRRSFGGQAGASARIENYFGFPTGITGQALTARG
FVQAQKFGVEIAIPTTITALTFGGAGGVNLLDAEDGRRYCARAVIVASGARYRRPPIGRL
AEFDGRGVWYWASPIEAQFCSRQEVVLVGGGNSAGQAAVFLAQHATKVRMMVRGPGLADT
MSRYLIDRIAADPRIELMPHTEIVSLDGDETGLRSLTWRDRMSGEETNAPIRNLFLFIGA
DPASDWLASCGMALDDKGFVMTDGSLETDLPGIFAIGDIRAGSVKRVGGAIGEGAAVVAR
IHAYLAHRRDEPSQPRRPSPNAPFEEAKPHKGEP