Protein Info for ABIE41_RS06590 in Bosea sp. OAE506

Annotation: non-homologous end-joining DNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 343 TIGR02779: DNA ligase D, ligase domain" amino acids 42 to 337 (296 residues), 312.5 bits, see alignment E=1.4e-97 PF01068: DNA_ligase_A_M" amino acids 54 to 225 (172 residues), 107.9 bits, see alignment E=5.8e-35 PF04679: DNA_ligase_A_C" amino acids 245 to 332 (88 residues), 80.2 bits, see alignment E=1.3e-26

Best Hits

KEGG orthology group: None (inferred from 61% identity to atu:Atu5051)

Predicted SEED Role

"ATP-dependent DNA ligase (EC 6.5.1.1) clustered with Ku protein, LigD" in subsystem DNA Repair Base Excision (EC 6.5.1.1)

Isozymes

Compare fitness of predicted isozymes for: 6.5.1.1

Use Curated BLAST to search for 6.5.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (343 amino acids)

>ABIE41_RS06590 non-homologous end-joining DNA ligase (Bosea sp. OAE506)
MAKRLLKVGVGDDVARSHVVATRRNRRQSELRFDPMPERVEPCLALLAAKAPTTSDWAME
VKWDGYRLAVHIERGKVRILTRGGHDWTTRFPTIAHDALEMGLDSAILDGEAVVLDERGA
SDFGALQRALGGRGGKRSAAGALLYAFDLLYLDGRDLRGMALDERRDMLTRAIRPHGSIR
LSEELNADGAAFLKLACELGLEGIIAKRRDAPYRSGRGGDWLKIKCVQSETFLILGYEPS
AAALGGIGRLLLAARNGDSLAYVGSVGTGFTTMTATELKRQLKTLEIPKPAIPIKAKGTI
WVTPTLPAEIAFRGWTNDNNLRHASYKGLREEADVEDLYEIDA