Protein Info for ABIE41_RS06025 in Bosea sp. OAE506

Annotation: hydroxyacylglutathione hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 254 TIGR03413: hydroxyacylglutathione hydrolase" amino acids 7 to 254 (248 residues), 232.3 bits, see alignment E=2.8e-73 PF00753: Lactamase_B" amino acids 17 to 170 (154 residues), 66.6 bits, see alignment E=3e-22 PF16123: HAGH_C" amino acids 171 to 254 (84 residues), 72.4 bits, see alignment E=3.2e-24

Best Hits

Swiss-Prot: 49% identical to GLO2_METNO: Hydroxyacylglutathione hydrolase (gloB) from Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)

KEGG orthology group: K01069, hydroxyacylglutathione hydrolase [EC: 3.1.2.6] (inferred from 49% identity to mno:Mnod_0448)

Predicted SEED Role

"Hydroxyacylglutathione hydrolase (EC 3.1.2.6)" in subsystem Glutathione: Non-redox reactions or Methylglyoxal Metabolism (EC 3.1.2.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.2.6

Use Curated BLAST to search for 3.1.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (254 amino acids)

>ABIE41_RS06025 hydroxyacylglutathione hydrolase (Bosea sp. OAE506)
MALDLHVFRTLGDNAGALLHDPASGTCAAIDVPDAGQVMAAAQAKGWTISEIFVTHAHAD
HTQGVAAVKQATGAKVCGPADAAGQAPLDRILSEGDAVSFGGVSFEIWHTPGHSDGHLSF
VSRGEKLAFVGDVVFLMGCGRVQPGQMAAMWTSLSRLMALPGDIRLLAGHDYTLSNARFA
AAMEPANAALAARLAEAEASKAEGRFWALTTVAEEAATNPFFRAGEGSLAAAVGLVGAPA
GEVFAALREAKNRF