Protein Info for ABIE41_RS04445 in Bosea sp. OAE506

Annotation: ATP-dependent protease ATPase subunit HslU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 5 to 436 (432 residues), 605.5 bits, see alignment E=3.3e-186 PF07728: AAA_5" amino acids 52 to 89 (38 residues), 27.3 bits, see alignment 8.3e-10 PF00004: AAA" amino acids 53 to 99 (47 residues), 29.3 bits, see alignment 2.7e-10 amino acids 228 to 325 (98 residues), 30.9 bits, see alignment E=8.4e-11 PF07724: AAA_2" amino acids 201 to 322 (122 residues), 84.7 bits, see alignment E=1.9e-27

Best Hits

Swiss-Prot: 81% identical to HSLU_METNO: ATP-dependent protease ATPase subunit HslU (hslU) from Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 81% identity to mno:Mnod_5465)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (436 amino acids)

>ABIE41_RS04445 ATP-dependent protease ATPase subunit HslU (Bosea sp. OAE506)
MTSFSPREIVSELDRFIVGQNDAKRAVAIALRNRWRRQQLEGPLREEVSPKNILMIGPTG
CGKTEIARRLAKLANAPFLKVEATKFTEVGYVGRDVESIVRDLVEIAIALVRENRRKDVQ
AKAHVAAEERVLDALVGVNASPATRDSFRRKLRANELDDKEIEVEIAAGSGASAPMFEVP
GMPGASIGAINLSDMFGKAFGQKGKPRRILVKDAYGPLLTEESDKLIDQEAIVQAAIREV
ENNGIVFLDEIDKICAREGKGGADVSREGVQRDLLPLIEGTTVATKHGAVKSDHILFIAS
GAFHVSRPSDLLPELQGRLPIRVELSPLDVDDFRRILTETEASLIKQTVALMATEEVTVD
FTPDAIDAIARIAVDVNSTVENIGARRLQTVIERILDDVSFTAPDRSGETVTIDAAYVQS
RIGDLAKNADLSRFIL