Protein Info for ABIE41_RS03580 in Bosea sp. OAE506
Annotation: fumarylacetoacetate hydrolase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 43% identical to FAHD1_RAT: Acylpyruvase FAHD1, mitochondrial (Fahd1) from Rattus norvegicus
KEGG orthology group: None (inferred from 64% identity to acr:Acry_0415)MetaCyc: 54% identical to 3-fumarylpyruvate hydrolase (Bradyrhizobium sp. JS329)
RXN-10445 [EC: 3.7.1.20]
Predicted SEED Role
"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism
MetaCyc Pathways
- gentisate degradation I (1/3 steps found)
- 5-nitroanthranilate degradation (2/6 steps found)
- 3-phenylpropanoate degradation (4/10 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.7.1.20
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (228 amino acids)
>ABIE41_RS03580 fumarylacetoacetate hydrolase family protein (Bosea sp. OAE506) MTNYVIDPPAVTAVPVAGGGMFPVRRVFCVGRNYAEHTREMGGDPDREEPFFFSKPADAL VINGADTPYPTKTADLHHEMELVVAIGTGGKDIAEADALAHVFGYAAGLDMTRRDLQAAA KKAGRPWDMAKGFDLSGPVGEIAPASQIGHPAAGKIELVVNGVPRQSSDLAKQIWNVPET ISYLSGLVELAPGDLIFTGTPEGVAAVVRGDVLEGEIAGVGTVRTRIA