Protein Info for ABIE40_RS28400 in Rhizobium sp. OAE497

Annotation: HD-GYP domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 321 transmembrane" amino acids 154 to 171 (18 residues), see Phobius details PF11871: DUF3391" amino acids 2 to 121 (120 residues), 49.6 bits, see alignment E=9.4e-17 PF13487: HD_5" amino acids 148 to 306 (159 residues), 119.7 bits, see alignment E=1.8e-38 PF01966: HD" amino acids 154 to 275 (122 residues), 57.7 bits, see alignment E=2.1e-19

Best Hits

KEGG orthology group: None (inferred from 66% identity to rle:pRL120258)

Predicted SEED Role

"Two-component response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (321 amino acids)

>ABIE40_RS28400 HD-GYP domain-containing protein (Rhizobium sp. OAE497)
MLKRIRLQELRVGMFIEEVESGSQVQSMLFSPFMVSSASDLRRMLNSNVMTLVIDVGKGR
DTERYAVPTQPFDRAHFEAMLLQKFSAGDVSRAKRCIEETKPHIRQVLSDARIKGGIASE
AADVAVERIMSAASRNAGALIGVAKLKEKDEITFLHSLAVSALMISFGRALGLTEGDVRI
LGLGGLVHDLGKMALPDGILKNTGKLTGQEMELVRLHPQRGYHLVSSLPDTPRWVLDICL
HHHEKFDGSGYPSGLAGERIPYVARLAAICDVYDALTTVRPYKQAWSQAEAIDMMMRSPG
HFDPTLLAAFVSKMVISGTLH