Protein Info for ABIE40_RS28180 in Rhizobium sp. OAE497
Annotation: zinc-dependent alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 60% identical to FADH_METMR: S-(hydroxymethyl)glutathione dehydrogenase (fdh) from Methylobacter marinus
KEGG orthology group: None (inferred from 94% identity to rlt:Rleg2_4725)Predicted SEED Role
"Threonine dehydrogenase and related Zn-dependent dehydrogenases" in subsystem Threonine degradation
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (391 amino acids)
>ABIE40_RS28180 zinc-dependent alcohol dehydrogenase (Rhizobium sp. OAE497) MRALVWHGKEDIRCDTVSDPEIEHPRDAIIKVTSCAICGSDLHLFHNFIPAMKPGDIMGH EMMGEVVETGSEASGGLKKGDRIVVPFTINCGECDQCKRGNFSVCERTNRNKDLADKTFG HTTAGLFGYTHLTGGYPGGQAEYLRVPFADKTHIKVPDSLTDEQVLFLGDIFPTGWQAAA QCDIEPADTVVVWGCGPVGQMTIRSAVLLGAKQVVAIDCIPERLSMAEAGGAITINFMDE SVVERLNDLTDGKGPEKCIDAVGLESHVSMGQPDTLLDRVKQVVMLEDDRPHVLREMIYV CRPGGIISIPGVYSGLVDKIPMGQAMNKGLSFRMGQTHVRRWTDDLLRRIEEGQIDPSFV ITHTVGLEQGPEMYRVFRDKQDSCIKVVLKP