Protein Info for ABIE40_RS24310 in Rhizobium sp. OAE497

Annotation: HAMP domain-containing sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 161 to 181 (21 residues), see Phobius details PF00672: HAMP" amino acids 180 to 229 (50 residues), 29.1 bits, see alignment 1e-10 PF02518: HATPase_c" amino acids 334 to 435 (102 residues), 81.7 bits, see alignment E=5.4e-27

Best Hits

KEGG orthology group: None (inferred from 78% identity to rlg:Rleg_2274)

Predicted SEED Role

"sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (440 amino acids)

>ABIE40_RS24310 HAMP domain-containing sensor histidine kinase (Rhizobium sp. OAE497)
MSAVALATFGRVWPSTLRSRIAIILLLGLAIAYGLSFSVLYAERMMSAKAVMLGTLESDV
ATSIAVLDRLPADQRADLTDPLSRGNYRFVLGPGLPGVPDHSTRGGEIAATISDAIGHRF
PIRMEAIPGDVTRLQAHLTLTDGTPLTIDITPRGIMPLAGWLPYVFVVQMLLIVLLTWLA
VRQATRPLADLAAAADALDPNKKGEVMSDSGPSEVAHAARAFNAMRDRIAHYLEERVQIL
AAISHDLQTPITRMRLRADMADESPERTKLLHDIGEIERLVQDGIAYARSSHGNGEKFSR
IDLASFIESLCYDYQDTGKPVSVLGLVSGTASTKPHALRRILSNFIDNALKFGGTAEVSV
ERREEGAIAITVMDRGPGIPGDQIEAAMQPFFRLEQSRNRETGGSGLGLAIAQQLTAAIG
GTMRLYNRDGGGLAAELVIH