Protein Info for ABIE40_RS23445 in Rhizobium sp. OAE497

Annotation: trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1233 PF18327: PRODH" amino acids 29 to 76 (48 residues), 67.1 bits, see alignment (E = 2.7e-22) PF14850: Pro_dh-DNA_bdg" amino acids 84 to 195 (112 residues), 156.3 bits, see alignment E=8e-50 PF01619: Pro_dh" amino acids 204 to 502 (299 residues), 347.6 bits, see alignment E=1.2e-107 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 539 to 1033 (495 residues), 686.2 bits, see alignment E=1.2e-210 PF00171: Aldedh" amino acids 589 to 1025 (437 residues), 334.3 bits, see alignment E=2e-103

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 64% identity to aav:Aave_3321)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1233 amino acids)

>ABIE40_RS23445 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase (Rhizobium sp. OAE497)
MLTDVADNASGSNPNSPFAQFAPPIREQSALRKAITAAYRRPETECLPPLVAAAKVPDDL
KTTIRGTARKLIEALRAKHKGTGVEGLVQEYSLSSQEGVALMCLAEALLRIPDTATRDAL
IRDKISEGDWKSHVGGGRSLFVNAATWGLVVTGKLTSTVNDRSLAAALTRLIARCGEPVI
RRGVDMAMRMMGEQFVTGETIDEALKRARPLEARGFRYSYDMLGEAATTAKDAERYYRDY
ENAINAIGKAAAGRGIYEGPGISIKLSALHPRYVRAQSKRVMEELLPRVQKLALLARTYD
IGLNIDAEEADRLELSLDLLEELSFDPALKGWNGLGFVVQGYGKRCPFVIDYIIDLSRRS
GRRMMVRLVKGAYWDAEIKRSQLDGLSDFPVYTRKIHTDVAYVACARKLLAATDAVFPQF
ATHNAQTLATIYHLAGNDFQVGKYEFQCLHGMGEPLYDEVVGKDKLDRPCRIYAPVGTHE
TLLAYLVRRLLENGANSSFVNRISDPKVSVDDLTADPVDLVEAMTPPGKPHDLISLPDDL
YGAERRNSAGIDLANEAELARLGGNLSKTVTMTWHALPLLADGDTQGVTRPILNPADHGD
AVGEVTEVEPAAVAKIAKLAAIGATEWAQVSPADRAACLDRAADIMQSRIETLMGVIMRE
AGKSAANSIGEVREAIDFLRYYAEQARRTLGPSHAPLGPIVCISPWNFPLAIFTGQVAAA
LVAGNSVIAKPAGVTPIVAFESVKILHEAGIPRHALQFTPGDGPLGAALIDAPETAGVMF
TGSTGVARLIQAQLANRLSNSGKPIPLIAETGGQNGMIVDSSALAEQVVGDVIASAFDSA
GQRCSALRVLCLQDDIADRTLTMLKGALQELSIGRTDRLSVDVGPVITATAKAGIDGHIE
KMKALGCKVEQLPLPETATLGTFVPPTIIELKKLSDLEKEVFGPVLHIIRYRRADLDRLI
DDINGSGYGLTFGLHTRLDETIAHVTSRVQAGNLYVNRNIIGAVVGVQPFGGRGLSGTGP
KAGGPLYIGRLVQKAPVPPQHSSVHTDPALADFAVWLSGKGKADDAEAARELGSLSAVGL
QKELVGPVGERNLYALHPRGRVLLAPSSERGLYRQIAAGLATGNQLVIDEVSGLRQALKD
LPASVAHRISWTSDWNKDGPFASALVEGDAERILTVNKAIAALDGPLVLVQSATTAEIES
DIEAYCLNWLVEEVSTSINTAAAGGNASLMTIG