Protein Info for ABIE40_RS21900 in Rhizobium sp. OAE497

Annotation: dihydrodipicolinate synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00701: DHDPS
  • amino acids 6 to 237 (232 residues), 114.8 bits, E=1.7e-37

Best Hits

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 91% identity to smk:Sinme_3914)

MetaCyc: 73% identical to Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase subunit (Pseudomonas putida KT2442)
1-pyrroline-4-hydroxy-2-carboxylate deaminase. [EC: 3.5.4.22]

Predicted SEED Role

"1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 3.5.4.22)

MetaCyc Pathways

• trans-4-hydroxy-L-proline degradation II (2/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52

Use Curated BLAST to search for 3.5.4.22 or 4.2.1.52

Protein Sequence (320 amino acids)

>ABIE40_RS21900 dihydrodipicolinate synthase family protein (Rhizobium sp. OAE497)
MKAKIFSGVIPALMTPCKKDRTPDFDQLVRKGKQLIADGMSAVVYCGSMGDWPLLSDEQR
MEGVERLVKAGVPVIVGTGAVNTASAVDHAAHAQKVGAQGLMVIPRVLSRGSVIAAQKAH
FKAILSAAPDLPAVIYNSPYYGFATRADLFFALRAEHSNLVGFKEFGGPADMRYAAENIT
SRDDGVSLMIGVDTAVFHGFVNCGATGAITGIGNVLPKEVITLCNLSQAAAKGDVDARQR
AQELEQALAVLSSFDEGPDLVLFFKHMMVLKGDEEYTLHFNESDVLSDSQRGYVESQFKL
FNSWYAEWSKLPGAVAKYKA