Protein Info for ABIE40_RS21555 in Rhizobium sp. OAE497

Annotation: carboxymuconolactone decarboxylase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02627: CMD
  • amino acids 36 to 117 (82 residues), 71.5 bits, E=2.3e-24

Best Hits

KEGG orthology group: K01607, 4-carboxymuconolactone decarboxylase [EC: 4.1.1.44] (inferred from 94% identity to rec:RHECIAT_PC0000387)

Predicted SEED Role

"4-carboxymuconolactone decarboxylase (EC 4.1.1.44)" in subsystem Protocatechuate branch of beta-ketoadipate pathway (EC 4.1.1.44)

MetaCyc Pathways

• aromatic compounds degradation via β-ketoadipate (8/9 steps found)
• protocatechuate degradation II (ortho-cleavage pathway) (4/4 steps found)
• toluene degradation III (aerobic) (via p-cresol) (7/11 steps found)
• superpathway of aerobic toluene degradation (10/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (12/35 steps found)

KEGG Metabolic Maps

• Benzoate degradation via hydroxylation

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.44

Use Curated BLAST to search for 4.1.1.44

Protein Sequence (129 amino acids)

>ABIE40_RS21555 carboxymuconolactone decarboxylase family protein (Rhizobium sp. OAE497)
MDEALRKSGEAVRRKVLGDDYVDRAINGADSFSAPFQDVLNEYCWGTAWTDEGLDLKQRS
LLNLGMLAALNRMHEFGIHFRGAIRNGLTDDELRAALVQIAVYCGIPAGVEAFRVARSIR
EEMRQKGEL