Protein Info for ABIE40_RS21030 in Rhizobium sp. OAE497
Annotation: aldehyde dehydrogenase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 49% identical to AL7A1_DICDI: Putative aldehyde dehydrogenase family 7 member A1 homolog (DDB_G0276821) from Dictyostelium discoideum
KEGG orthology group: None (inferred from 85% identity to smk:Sinme_3282)MetaCyc: 69% identical to L-aminoadipate-semialdehyde dehydrogenase (Pseudomonas putida)
L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.31]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- L-lactaldehyde degradation (aerobic) (2/2 steps found)
- superpathway of fucose and rhamnose degradation (9/12 steps found)
- methylglyoxal degradation IV (2/3 steps found)
- methylglyoxal degradation V (2/3 steps found)
- lactate biosynthesis (archaea) (3/5 steps found)
- superpathway of methylglyoxal degradation (5/8 steps found)
- L-rhamnose degradation II (4/8 steps found)
- L-lysine degradation V (4/9 steps found)
- L-lysine degradation II (L-pipecolate pathway) (2/9 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.22
Use Curated BLAST to search for 1.2.1.22 or 1.2.1.31
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (510 amino acids)
>ABIE40_RS21030 aldehyde dehydrogenase family protein (Rhizobium sp. OAE497) MNISVKSSSVLDEAHAILDRLGVDKSAYTDGSMVSFSPITGEKIGKLKTVDAKGAAAAIE EAHAAFQTWRLTPAPKRGELVRLLGEELRAAKADLGRLVSIEAGKIPSEGLGEVQEMIDI CDYAVGLSRQLYGLTIATERPGHRMMETWHPLGVVGIISAFNFPVAVWSWNAALALVCGN SVVWKPSEKTPLTALASQAILERALKRFGDAPAGLSQVIIGGREIGEALVDHKNVALVSA TGSTRMGREVGPRLAKRFARSILELGGNNGGIVCPSADLDMALRAIAFGAMGTAGQRCTT LRRLFVHDSVYEELVPRLKKAYASVSVGNPLDSAALVGPLVDKAAYDGMQKALGEARAHG GNVHGGDRVDLGHPDAYYVKPALVEMPKHEGPVFEETFAPILYVMKYSDFDAVIADHNAV GAGLSSSIFTLDMREAERFLAADGSDCGIANVNIGTSGAEIGGAFGGEKETGGGRESGSD AWRAYMRRATNTINYSKALPLAQGVSFDIA