Protein Info for ABIE40_RS19250 in Rhizobium sp. OAE497

Annotation: shikimate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00507: shikimate dehydrogenase
  • amino acids 14 to 276 (263 residues), 210.2 bits, E=1.6e-66
• PF08501: Shikimate_dh_N
  • amino acids 14 to 98 (85 residues), 80 bits, E=1.9e-26
• PF01488: Shikimate_DH
  • amino acids 129 to 200 (72 residues), 41.5 bits, E=2.2e-14
• PF18317: SDH_C
  • amino acids 248 to 277 (30 residues), 27.1 bits, see alignment (E = 4.3e-10)

Best Hits

Swiss-Prot: 82% identical to AROE_RHIE6: Shikimate dehydrogenase (NADP(+)) (aroE) from Rhizobium etli (strain CIAT 652)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 82% identity to rec:RHECIAT_CH0000004)

Predicted SEED Role

"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of chorismate metabolism (37/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.25

Protein Sequence (285 amino acids)

>ABIE40_RS19250 shikimate dehydrogenase (Rhizobium sp. OAE497)
MDDSRETFGQNAFVTGFPVKHSRSPLIHGHWLRSLGLAGSYRAHEVAPEQFGAFIAGIKD
GSSGFIGGNVTIPHKELAFQLADRPDALSEELGASNTLWMEEGKLHASNTDGRGFTANLD
ERHPGWDQTDTAVIFGAGGASRAVIQAIRDRGLKNIHVVNRTISRAQELADRFGPAIHAH
PTDALGEVMKGAGLFINTTSLGMDGEAAPQMDFSPLASGAVVTDIVYVPLLTPMLIQAEE
QGFATVDGLGMLLHQAVPGFAKWFGKTPVVDEALRALIIADMEKH