Protein Info for ABIE40_RS19060 in Rhizobium sp. OAE497

Annotation: lipid A 1-phosphatase LpxE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 242 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 68 to 89 (22 residues), see Phobius details amino acids 101 to 122 (22 residues), see Phobius details amino acids 154 to 173 (20 residues), see Phobius details amino acids 178 to 197 (20 residues), see Phobius details amino acids 203 to 228 (26 residues), see Phobius details PF01569: PAP2" amino acids 106 to 219 (114 residues), 89.4 bits, see alignment E=8.7e-30

Best Hits

Swiss-Prot: 65% identical to LPXE_RHIL3: Lipid A 1-phosphatase (lpxE) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: None (inferred from 65% identity to rle:RL4708)

Predicted SEED Role

"Phosphatidylglycerophosphatase B (EC 3.1.3.27)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 3.1.3.27)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.27

Use Curated BLAST to search for 3.1.3.27

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (242 amino acids)

>ABIE40_RS19060 lipid A 1-phosphatase LpxE (Rhizobium sp. OAE497)
MQAILSSLDRRWRRSTCRMPQLRWQTCLFITCNAVLLSMLLLDGPVGAGQVPPVIRRLGR
ILTDFGTSGWIIIVSAFLFFEGLAALRIVRSLRTRIQALQMCWIGAYLLISIALSGILAN
ILKRAIGRARPQHFDDYGIFSFSPFSGHAAFESFPSGHATTIGAFFAALSLLFPRYRVVF
LACALWLGMTRVMVSAHYPSDVIAGLALGGWFSLMIAIVFSRYGILFRVADGWPVPKRML
RA