Protein Info for ABIE40_RS15580 in Rhizobium sp. OAE497

Annotation: ATP-dependent zinc metalloprotease FtsH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 643 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 106 to 126 (21 residues), see Phobius details PF06480: FtsH_ext" amino acids 9 to 98 (90 residues), 66 bits, see alignment E=8.1e-22 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 107 to 599 (493 residues), 785.4 bits, see alignment E=1.1e-240 PF07728: AAA_5" amino acids 193 to 315 (123 residues), 30.4 bits, see alignment E=9.2e-11 PF00004: AAA" amino acids 194 to 326 (133 residues), 161.9 bits, see alignment E=2.8e-51 PF17862: AAA_lid_3" amino acids 349 to 393 (45 residues), 60.4 bits, see alignment 2.3e-20 PF01434: Peptidase_M41" amino acids 408 to 598 (191 residues), 234.2 bits, see alignment E=3e-73

Best Hits

Swiss-Prot: 73% identical to FTSH_BARBK: ATP-dependent zinc metalloprotease FtsH (ftsH) from Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 96% identity to rlg:Rleg_3491)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (643 amino acids)

>ABIE40_RS15580 ATP-dependent zinc metalloprotease FtsH (Rhizobium sp. OAE497)
MNPNLRNFALWAIIALLLIALFSMFQTTPAQTSSREIPYSQFLREVDAGRVKEVVVTGNR
VSGSYVENGTTFQTYSPVIDDSLLDRLQTKNVLVSARPETDGSSGFLSYLGTLLPMLLIL
GVWLFFMRQMQGGSRGAMGFGKSKAKLLTEAHGRVTFEDVAGVDEAKQDLEEIVEFLRDP
QKFQRLGGKIPRGVLLVGPPGTGKTLLARSVAGEANVPFFTISGSDFVEMFVGVGASRVR
DMFEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEANEGIILI
AATNRPDVLDPALLRPGRFDRQVVVPNPDIVGRERILKVHARNVPLAPNVDLKTLARGTP
GFSGADLMNLVNEAALMAARRNKRVVTMQEFEDAKDKIMMGAERRSSAMTEAEKKLTAYH
EAGHAITALKVAVADPLHKATIIPRGRALGMVMQLPEGDRYSMSYKWMVSRLVIMMGGRI
AEELTFGKENITSGASSDIEQATKLARAMVTQWGFSDVLGQVAYGENQQEVFLGHSVSQS
KNVSEATAQKIDSEVRRLIEDAYTEARQILTDNHDEFVAIAEGLLEYETLTGEEIKALIR
GEKPARDLGDDTPPSRGSAVPKAGARPASKGDEAEGGLEPQPH