Protein Info for ABIE40_RS14515 in Rhizobium sp. OAE497

Annotation: HWE histidine kinase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 855 PF08446: PAS_2" amino acids 13 to 119 (107 residues), 68.1 bits, see alignment E=3.1e-22 PF01590: GAF" amino acids 145 to 308 (164 residues), 56.2 bits, see alignment E=1.6e-18 PF00360: PHY" amino acids 323 to 500 (178 residues), 157.5 bits, see alignment E=7e-50 PF07568: HisKA_2" amino acids 522 to 572 (51 residues), 26.2 bits, see alignment 2.1e-09 PF07536: HWE_HK" amino acids 522 to 603 (82 residues), 75.6 bits, see alignment E=1.3e-24 PF00072: Response_reg" amino acids 742 to 844 (103 residues), 30.9 bits, see alignment E=7.7e-11

Best Hits

KEGG orthology group: None (inferred from 68% identity to rlg:Rleg_3289)

Predicted SEED Role

"Phytochrome, two-component sensor histidine kinase (EC 2.7.3.-)" in subsystem Oxidative stress or Oxygen and light sensor PpaA-PpsR (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (855 amino acids)

>ABIE40_RS14515 HWE histidine kinase domain-containing protein (Rhizobium sp. OAE497)
MSETFDRVDLTNCDREPIHRLGAIQPFGFLLVSSPDWLISRASENLEQLLGVSHRDVLGH
PLSEVIMSQTLHTLRNRLAVIRGPDIVERLFGIQFSESGPLFDVALHISDGQVVIEAEPS
QDGSQGGTTLSIRSMMARLDQAETMEAFFREGARQARALTGFDRVMVYRFDEKGSGEVVA
EAARPGIGSFLGLHYPASDIPVQARALYVRNLFRIIADVNSTPVGIQPEVDEHGRALDLS
MSILRSVSPIHIEYLKNMGVGASLSISIIVDGKLWGLFACHHYSARLPSFERRSTSELFG
QMFASRLESRERRLALEFETKARRIADRLLTSVADNASLLDDPTWLIDALSDAIPADGIG
VWINGRSALTGLAPSQEQFAGLVRVLNRTSSGRVFTTDHLEEFFPDSGIDGTVAGLMAIP
ISRSPRDYVILFRQEIVRTVRWAGDPHKPVEYGPNGPRLTPRKSFESWSELVRGRSQPFT
AAEKRVADTIRVTLIEVILRLADEASAVRQQANERQEILIAELNHRVRNILSLISGLIRQ
SRTGDGDIGEFVGQLEGRVQALSRAHDQITRDHWAPASLRSLLQAEAAAYLGKNAARVIM
RGDEVLLGPQAFSTAALVFHELVTNSAKYGSLCDSGTVAVSWKKDAKGNLLIEWREADGP
AVKAPKRQGFGTTIIRHSIPYDLGGKAEVRYAPSGLEADFTIPAKYVTFAQGPVSILPET
REEPVARAATAISEKPLQGCSILLVEDNLIIAMDGEDIFLQLGAKDVALAPSVAQALDIV
ATRHFDLAVLDVNLGEETSFPVAEKLVKAGTPLVFATGYGEAVTRNFNGANILQKPYTIE
SVAAALDKMMPLKKA