Protein Info for ABIE40_RS11655 in Rhizobium sp. OAE497

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1050 transmembrane" amino acids 24 to 45 (22 residues), see Phobius details amino acids 344 to 361 (18 residues), see Phobius details amino acids 368 to 388 (21 residues), see Phobius details amino acids 394 to 419 (26 residues), see Phobius details amino acids 439 to 459 (21 residues), see Phobius details amino acids 471 to 494 (24 residues), see Phobius details amino acids 530 to 550 (21 residues), see Phobius details amino acids 857 to 876 (20 residues), see Phobius details amino acids 884 to 904 (21 residues), see Phobius details amino acids 910 to 933 (24 residues), see Phobius details amino acids 958 to 979 (22 residues), see Phobius details amino acids 987 to 1013 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 17 to 1013 (997 residues), 902.1 bits, see alignment E=4.5e-275 PF03176: MMPL" amino acids 303 to 496 (194 residues), 25.6 bits, see alignment E=5.9e-10 amino acids 808 to 1028 (221 residues), 21.1 bits, see alignment E=1.4e-08

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 92% identity to rlt:Rleg2_2556)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1050 amino acids)

>ABIE40_RS11655 efflux RND transporter permease subunit (Rhizobium sp. OAE497)
MSVTEIHDRASGKQSFTALFVRRPILALVFNTLMVVAGLAAYVGIEVRELPDVDRPVVTV
RTTFDGASPQTIDQELTKVIEGAVARVSGLKSISSQSQFGQSRVTLEFSDSVDLAVAAND
VRDAIGRITQNLPDDADAPQIVKADSDSQAIMRLAVTSSNLNMDDLTLLVENEIVDRLAS
VDGVADVEEYGDQEKVFRVDVDQSALASRGLTIGDLTQALSNAALDVPAGSLKSTTQDIV
VRATANLQKPEDFQNVILQDRVRLGDVATVTLGPRDGETALRSNGNPGIGLGIIRQAQSN
TLNISAGVHAAVEQLSKTLPEGTKIAITSDDAVFIQGAIHEVELALILAAVIVTAVIYLF
LRDWRATLIPAVSMPVALIGTLAAIYMVGFSINILTLLAIVLATGLVVDDAIVVLENIVR
RRAEGMGPRAAAVLGTREVFFAVIATTATLAAVFIPLSFLPGQVGGLFREFGFVLAFSVG
LSSLVALTLCPMLASRMLTKPMREDHGALGRFGNLFATAYKWGLQRCLNAPLVVIIVSLL
FGGAALLAFSTVKSELTPNEDRAMVMMRLTSPQGSSLEYTRDKMQLVEEYLQPLVDSGDI
QNVFSISGQGGQANSGFMVLTLAPWGERERTQAEIVQDINRAASRVPALRGNAISSNSLR
IRGAGNGLQMALIGNNYEDLTAAALKLVQALDATGQFDTPRLTNEPTQAQVSVSIDRERA
SDLGIDITGLSTAIQSLLEGRSVVDVFVDGESYPVLLTSTTRPIDDPTDLENVFLKTGDG
KIVPMSVIASLKEGSVAPQLNRESQLASVAITAGLKDGMSLGDAVNQVTQLAEPLLPSGA
RLLPLAEAATLEENSSGMALTFGFAIVIIFLVLAAQFESVLSSLIIMSTVPLGLACAVFA
LIITGSSLNIYSQIGLVLLVGVMAKNGILIVEFANQLRDHGVEVREAIERACELRLRPVM
MTMIATILGGVPLVFAHGAGAEARVALGWVIVGGLGFATLVTLFITPVAYLLIARFAKPH
AHEEARLHEEMSHATRPKVVPDAEQLQAAE