Protein Info for ABIE40_RS06030 in Rhizobium sp. OAE497

Annotation: 4-hydroxy-tetrahydrodipicolinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00701: DHDPS
  • amino acids 2 to 280 (279 residues), 297 bits, E=5.1e-93
• TIGR00674: 4-hydroxy-tetrahydrodipicolinate synthase
  • amino acids 4 to 279 (276 residues), 313.9 bits, E=3.5e-98

Best Hits

Swiss-Prot: 82% identical to DAPA_AGRFC: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 89% identity to ret:RHE_CH01381)

MetaCyc: 45% identical to 4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli K-12 substr. MG1655)
DIHYDRODIPICSYN-RXN [EC: 4.3.3.7]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• L-lysine biosynthesis II (8/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• dipicolinate biosynthesis (3/4 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7

Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7

Protein Sequence (294 amino acids)

>ABIE40_RS06030 4-hydroxy-tetrahydrodipicolinate synthase (Rhizobium sp. OAE497)
MFKGSIPALVTPFTDSGNVDEAAFAAHVDWQIKEGSSGLVPVGTTGESPTLSHAEHKRVV
ELCIEAAAKRVPVMAGAGSNNTREAIELAQHAEKAGADAVLVVTPYYNKPTQKGLIAHFS
AIAEAVKLPIYIYNIPGRSVIDMSPETMGVLAKAHSNIVGVKDATGKIERVSDQRITCGN
DFRQLSGEDATALGFNAHGGVGCISVVANIAPRLCAEFQAATLAGDYVKALEYQDRLMPL
HKAVFMEPGVCGAKYGLNKLGRMSRNVRSPLVSSLEAGTEAAMDAALRHAGLLN