Protein Info for ABIE40_RS05955 in Rhizobium sp. OAE497

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 transmembrane" amino acids 23 to 45 (23 residues), see Phobius details amino acids 50 to 74 (25 residues), see Phobius details amino acids 97 to 118 (22 residues), see Phobius details amino acids 138 to 158 (21 residues), see Phobius details amino acids 168 to 189 (22 residues), see Phobius details amino acids 194 to 194 (1 residues), see Phobius details amino acids 197 to 218 (22 residues), see Phobius details amino acids 239 to 265 (27 residues), see Phobius details amino acids 276 to 300 (25 residues), see Phobius details amino acids 320 to 342 (23 residues), see Phobius details amino acids 362 to 383 (22 residues), see Phobius details amino acids 393 to 414 (22 residues), see Phobius details amino acids 420 to 440 (21 residues), see Phobius details PF01554: MatE" amino acids 25 to 186 (162 residues), 50.6 bits, see alignment E=8.9e-18 amino acids 245 to 410 (166 residues), 67.3 bits, see alignment E=6.8e-23

Best Hits

KEGG orthology group: None (inferred from 70% identity to rlg:Rleg_1128)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (455 amino acids)

>ABIE40_RS05955 MATE family efflux transporter (Rhizobium sp. OAE497)
MKPVSATNPFLTAPLPKVFARTAAPIILITTINGLFAVVDAYFLGAYVGAGALSAVTLIF
PGLMMVVALQSLVSNGMASILARELGAGNRDAARRTFAAAHVLAIAVVLIVNLIYWTIGW
RIVGNAAAGDIAVAENARTFMGIMVGVAPVAFFLSLNIDALRSEGRIGFMTLVMLAASAL
NIAANWFFMAILHWGVAGSALGSVLAQAICLIAVLVYRWRNAAALRPATRFPLSDWKPIL
ALGAPMSLGFIGISLCSAAVIFNLSIWGEGDYVATVGAYGIITRVMTVAYLPLLGLNIAF
QTIAGNNYGAGLRERVGRSLQIALISALVYCAGVELIVELSATRLGHIFVADPVVIAEVS
RILPWTVGAYFLFGQMIVLSGYFQAIGDAKRAAIFGLSRAYLFTLPLTFLLPHAFGEMGI
WMVPVFAEACMFMLAFAVLARNARRMGWRYGLLPV