Protein Info for ABIE40_RS05385 in Rhizobium sp. OAE497

Annotation: Nramp family divalent metal transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 transmembrane" amino acids 39 to 55 (17 residues), see Phobius details amino acids 70 to 96 (27 residues), see Phobius details amino acids 117 to 140 (24 residues), see Phobius details amino acids 144 to 167 (24 residues), see Phobius details amino acids 174 to 196 (23 residues), see Phobius details amino acids 220 to 239 (20 residues), see Phobius details amino acids 260 to 288 (29 residues), see Phobius details amino acids 309 to 337 (29 residues), see Phobius details amino acids 358 to 376 (19 residues), see Phobius details amino acids 383 to 407 (25 residues), see Phobius details amino acids 420 to 441 (22 residues), see Phobius details TIGR01197: metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family" amino acids 38 to 412 (375 residues), 390.8 bits, see alignment E=4.1e-121 PF01566: Nramp" amino acids 60 to 417 (358 residues), 439.9 bits, see alignment E=3.6e-136

Best Hits

Swiss-Prot: 80% identical to MNTH_AGRFC: Divalent metal cation transporter MntH (mntH) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K03322, manganese transport protein (inferred from 89% identity to rec:RHECIAT_CH0000968)

Predicted SEED Role

"Manganese transport protein MntH" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>ABIE40_RS05385 Nramp family divalent metal transporter (Rhizobium sp. OAE497)
MDVLNPQRKGGWRYERQEASLSDVYRSVNTRRDGSKLRRIAAFAGPGYMVAVGYMDPGNW
ATSLAGGSKFGYALLTVALLSNLMAIVLQSLCARLAIGSGRDLAQACRDAFPKWVSIPLW
AFAEIAIIATDIAEVIGTAIGLNLIFGVPLELGVLITALDVFLILYLQKMGFRWVEAFII
TLLGVIALCFGVQILLADPQWGAVLKGFFPTTEIVTNPEMLYLALGILGATVMPHNLYLH
SGIVQTRDFGHTLPEKREALTFATIDSTVALCFALLINASILILAAAAFNANGQTNIVEL
GEAHSLLAPLLGLAIAPTLFGIALLCCGLNSTVTATLAGQIVMEGFIKMKVQPWVRRLIT
RAIAIIPAAFVTIWYGDAGTAELLILTQVVLSLQLSFAVFPLVMFTASKAKMGELVAPRW
LSAIAYLIAIVIAGLNIKLLFDFVTG