Protein Info for ABIE40_RS05160 in Rhizobium sp. OAE497

Annotation: HAMP domain-containing sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 transmembrane" amino acids 43 to 61 (19 residues), see Phobius details amino acids 67 to 89 (23 residues), see Phobius details PF00512: HisKA" amino acids 242 to 311 (70 residues), 68.5 bits, see alignment E=4.3e-23 PF02518: HATPase_c" amino acids 358 to 465 (108 residues), 100 bits, see alignment E=1.1e-32

Best Hits

KEGG orthology group: K11357, two-component system, cell cycle sensor histidine kinase DivJ [EC: 2.7.13.3] (inferred from 80% identity to rec:RHECIAT_CH0001348)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>ABIE40_RS05160 HAMP domain-containing sensor histidine kinase (Rhizobium sp. OAE497)
MRVLSDIGNRAAALVDRAAASWLSRTGSGEAVAERELAILRRLALLSSGALIAAPAGLSF
ITSPAVALPAGVATVCAAFLFSAVGSIALSRQTQATVSVASQPAEDFFLENSAGLVLFLD
AQGNVTASGGRDISDYLAWMREPKGRGFIEQVHVSDRILFLQALDQLRQGDESVSVDLRL
DRPGVSRDLRQFAYLRMDMTARRDGEGQLAAVIAQLRDVSVEQQLRMDAQSRAADAESAN
DAKSRFLAAVSHELRTPLNAILGFSDILLGEYFGKFENERQREYVGLVRDSGAHLLSVVN
TMLDMSKIEAGRYELLLEPFDIGASIRSCEAMLALQAKSKGVTLTSRIQRDLDEVVADQR
AIQQILINLVGNAVKFTEQGGAVTVDASVRGGILQLSVSDTGIGIPTDKLAMLGQPFMQI
QNDYTRQYEGTGLGLSLVKGLVALHGGHFALASAPGEGTIITISIAADGSGAYAADAARE
TAVEFPPRLKTAAAPAAGLEEGLFDGRAQAKIA