Protein Info for ABIE40_RS04735 in Rhizobium sp. OAE497

Annotation: glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 779 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 28 to 48 (21 residues), see Phobius details amino acids 54 to 71 (18 residues), see Phobius details amino acids 77 to 99 (23 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details TIGR03074: membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family" amino acids 5 to 779 (775 residues), 1156.4 bits, see alignment E=0 PF13360: PQQ_2" amino acids 187 to 303 (117 residues), 27.5 bits, see alignment E=3.6e-10 amino acids 356 to 502 (147 residues), 21.4 bits, see alignment E=2.7e-08 PF01011: PQQ" amino acids 223 to 255 (33 residues), 26.7 bits, see alignment (E = 5.1e-10) amino acids 282 to 309 (28 residues), 21.2 bits, see alignment (E = 2.8e-08) amino acids 707 to 744 (38 residues), 22.3 bits, see alignment 1.3e-08

Best Hits

KEGG orthology group: K00117, quinoprotein glucose dehydrogenase [EC: 1.1.5.2] (inferred from 88% identity to ret:RHE_CH01222)

Predicted SEED Role

"Glucose dehydrogenase, PQQ-dependent (EC 1.1.5.2)" in subsystem D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway or Respiratory dehydrogenases 1 (EC 1.1.5.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.5.2

Use Curated BLAST to search for 1.1.5.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (779 amino acids)

>ABIE40_RS04735 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase (Rhizobium sp. OAE497)
MAIAITSILFLLIGLALGGGGLWLVLLGGSIFYLFAGAMFIITGVLLLMRKAVALWVYAA
LVVAALIWAVWEVGFDWWQLGPRGGLIILLGLWLLTPWIRRPLGFTSPTGAVYSANPWPL
GVPVIIAILVAGYSMTTDPHDLAGDLPKDVVAAAPPFGGDVPDGEWHQYGRTPFGQRYSP
LDQINATNVKDLKEVWRYQTGDVKRPDDVGETTYQVTPLKVNDTLYLCTPHNWAIALDAK
TGKEKWKFDANSGMNPDRQHQTCRGVTYYHDTATAAGQPCVDRVYLPTSDARLIALDAAD
GKVCESFADKGTLHLETGMKYNPAGYYYSTSPPVAVAGKLIIGGAVNDNYSTQEQSGVIR
AFDINTGALLWNWDSGNPDVTTPLPQGQTYTTNSPNSWSVLSVDEGLGMVYIPLGNQVPD
QLGMGRSANVEKFSSSVAALDINSGQLKWVQQFVHHDLWDMDVPAQPVLFDMTKPDGSVV
PALVAPTKQGDIYVLDRRTGEAIIPFKEIPAPSGAIPEDKTAPTQPISDLTFSPDPLQEK
NMWGISLFDQLACRIEFHRYKYEGRYTPPSLQGTIVYPGNFGTFNWGSVAVDPERQIMFG
MPTYLAFTSRLVPAADIPPRGQDEKGSEQGLNRNDGAPYGVFMGPFLGPLGIPCQAPPWG
YVAGVDLRTGKIAYMHKNGTVHDMTPLPLPFKVGVPGIGGPMMTKGGVAFLGAAVDNYLR
AYDVTSGAQLWQARLPAGGQATPMTYTTSDNKQYVVMVAGGHGSVGTKPGDYVIGYTLP