Protein Info for ABIE40_RS04520 in Rhizobium sp. OAE497

Annotation: betaine-aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01804: betaine-aldehyde dehydrogenase
  • amino acids 10 to 474 (465 residues), 780.3 bits, E=2.6e-239
• PF00171: Aldedh
  • amino acids 16 to 476 (461 residues), 579.5 bits, E=2.2e-178

Best Hits

Swiss-Prot: 93% identical to BETB_AGRRK: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Agrobacterium radiobacter (strain K84 / ATCC BAA-868)

KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 93% identity to ara:Arad_1352)

MetaCyc: 90% identical to betaine aldehyde dehydrogenase (Sinorhizobium meliloti Rm2011)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]

Predicted SEED Role

"Betaine aldehyde dehydrogenase (EC 1.2.1.8)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.2.1.8)

MetaCyc Pathways

• choline-O-sulfate degradation (3/3 steps found)
• choline degradation I (2/2 steps found)
• glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
• glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
• glycine betaine biosynthesis III (plants) (2/3 steps found)
• β-alanine biosynthesis I (1/2 steps found)
• β-alanine biosynthesis IV (1/2 steps found)
• choline degradation IV (2/4 steps found)
• dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
• dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.8

Protein Sequence (487 amino acids)

>ABIE40_RS04520 betaine-aldehyde dehydrogenase (Rhizobium sp. OAE497)
MKAQPKASHFIDGEYVEDDAGSVIESIYPATGEVIARLHAATPAIVEKAIAAAKRAQPEW
AAMSPTARGRILKRAAEIMRERNRELSELETLDTGKPIQETIVADPTSGADSFEFFGGIA
ATALNGSYIPLGGDFAYTKRVPLGVCVGIGAWNYPQQIACWKGAPALIAGNAMVFKPSEN
TPLGALKIAEILHEAGLPKGLYNVIQGDRETGPLLVNHPDVAKVSLTGSVPTGRRVAAAA
ASHLKHVTMELGGKSPLIVFDDADIDSAIGGAMLGNFYSTGQVCSNGTRVFVQKKIKGEF
LKRLKSRTEAMVIGDPMDEATQIGPMVSWAQRQKVLEYIEKGKAEGATLLTGGGIPNNVA
GEGYYVQPTVFADVTDEMTIAREEIFGPVMCVLDFDDEAEVIGRANATEFGLSGGVFTAD
MTRAHRVVDLLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAALEHYSELKTVYVGM
GPVQAPY