Protein Info for ABIE40_RS02475 in Rhizobium sp. OAE497

Annotation: ligase-associated DNA damage response DEXH box helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 836 TIGR04121: DEXH box helicase, DNA ligase-associated" amino acids 16 to 830 (815 residues), 1115.7 bits, see alignment E=0 PF04851: ResIII" amino acids 27 to 202 (176 residues), 26.3 bits, see alignment E=1.6e-09 PF00270: DEAD" amino acids 29 to 204 (176 residues), 105.6 bits, see alignment E=6.2e-34 PF00271: Helicase_C" amino acids 264 to 360 (97 residues), 61.3 bits, see alignment E=2.6e-20 PF19306: Lhr_WH" amino acids 404 to 555 (152 residues), 117.6 bits, see alignment E=1.1e-37 PF08494: DEAD_assoc" amino acids 613 to 802 (190 residues), 181.1 bits, see alignment E=5.6e-57

Best Hits

KEGG orthology group: K03724, ATP-dependent helicase Lhr and Lhr-like helicase [EC: 3.6.4.-] (inferred from 91% identity to rlt:Rleg2_0202)

Predicted SEED Role

"FIG003033: Helicase domain protein"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (836 amino acids)

>ABIE40_RS02475 ligase-associated DNA damage response DEXH box helicase (Rhizobium sp. OAE497)
MDHVDAETSIALPAPFIRWFAEKGWRPRAHQLELLARAEAGESTLLIAPTGAGKTLAGFL
PALTDLTRRGKIPPGSAFTGIHTLYVSPLKALAVDIERNLTKPVEEMGLPVTIENRTGDT
PNAKRQRQKLNPPDILLTTPEQVALLLANGEAERFFKDLRYVVLDELHSLVTSKRGHMLS
LGIARLRRLAPNLQTIGLSATVAEPMDLQKWLVAQEEGREHHAGLVTVEGGAKPEISILK
TEERIPWSGHSAKYAIPDVYKELLDHQTTLLFVNTRSQAEMLFQELWTINEDNLPIALHH
GSLDVSQRRKVEAAMAANKLRAVVATSTLDLGIDWGDVDLVIHVGAPKGASRLAQRIGRA
NHRMDEPSKAILVPANRFEVMECQAALDANYIGAQDTPPVGQGALDVLAQHVLGMACAAP
FDMLQLYDEITSASPYAALSWETFERIVDFVATGGYALRTYERYARIRRNKDGLWRVSNP
QVAQQYRLNLGTIVESPMLNLKMVKRGEGGRIGRGGAVLGKMEEYFFEQLSPGDTFIFSG
KVLRFEGIRENEALASQAFSLDPKIPSYAGGKFPLSTYLADQVRSMIADPDRWGDLPDQV
RDWLSIQKDKSMLPKRDELLIETFPRGSRCYMVAYPFEGRLAHQTLGMLLTRRLERAGAK
PLGFVCTDYSLGIWGLEDLGQMIASGRLSLADLFDEDMLGDELEAWLDESFLLKRTFRNC
AVIAGLIERRHPGKEKSGRQVTVSADLIYDVLRSHEPDHILLQATRQDAGTGLLDISRLG
DMLRRIKGHITHRALDHISPLAVPVMLEIGKEAVPGEAHDALLAEAADDLIAEAMS