Protein Info for ABIE40_RS01645 in Rhizobium sp. OAE497

Annotation: heat-inducible transcriptional repressor HrcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 363 TIGR00331: heat-inducible transcription repressor HrcA" amino acids 16 to 357 (342 residues), 316.6 bits, see alignment E=1.3e-98 PF01628: HrcA" amino acids 119 to 344 (226 residues), 191.4 bits, see alignment E=1e-60

Best Hits

Swiss-Prot: 92% identical to HRCA_RHIL3: Heat-inducible transcription repressor HrcA (hrcA) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K03705, heat-inducible transcriptional repressor (inferred from 92% identity to rlt:Rleg2_0007)

Predicted SEED Role

"Heat-inducible transcription repressor HrcA" in subsystem Heat shock dnaK gene cluster extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (363 amino acids)

>ABIE40_RS01645 heat-inducible transcriptional repressor HrcA (Rhizobium sp. OAE497)
MAFRSSPVSDAIAALDERSKEIFRRIVEGYLENGEPLGSRNLSRILPMSLSPASVRNVMS
DLEELGLIYSPHVSAGRLPTQVGLRFFVDAFMQVGDLSAEDRASIDRQVRAESRDNPVES
MMNEASRMLSGISRGAGLVITAKSDPILKHVEFIRLEPTKALAVLVGEHDQVENRIIELP
AGVTSSQLTEAANFLNAHMTGQTLPELRKQLDKLKIDVRHELDALSQDLVERGIAVWSGS
PDEGKPAQLIIRGRANLLEGLAGADDLDRLRMLFDDLEKKDSLIELLNLAESGPGVRIFI
GSENKLFSLSGSSLIVAPYRDDDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLISRLSRG
GAL