Protein Info for ABIE40_RS01575 in Rhizobium sp. OAE497

Annotation: aromatic amino acid lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00221: Lyase_aromatic
  • amino acids 16 to 463 (448 residues), 286.1 bits, E=2.4e-89

Best Hits

KEGG orthology group: K01745, histidine ammonia-lyase [EC: 4.3.1.3] (inferred from 90% identity to rle:RL0369)

Predicted SEED Role

"Aromatic amino acid ammonia-lyase family"

MetaCyc Pathways

• L-histidine degradation II (5/5 steps found)
• L-histidine degradation VI (7/8 steps found)
• L-histidine degradation I (3/4 steps found)
• L-histidine degradation III (4/6 steps found)

KEGG Metabolic Maps

• Histidine metabolism
• Nitrogen metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.3

Use Curated BLAST to search for 4.3.1.3

Protein Sequence (527 amino acids)

>ABIE40_RS01575 aromatic amino acid lyase (Rhizobium sp. OAE497)
MKHERPGIELSGQPLGFAEMVRIGSGKVALSASAAGMARVEHARSIVEDAIDAGVPVYGS
TTGVGAMKDVEWSNDELEAFNLGLVRAHHFGTGTPFSCAVVRNAMAIRINTALTGQVGCT
PELIEAYMRLLDADLIPLVRRTGSIGCADIGLMGQIGAVLTGVGEAVYRGKRMQAAEAFQ
AAGLEPIKMAPRDSLASLSVNAVSFAAAGEATRNAAASIRVLLATGMMASGALGASRDPW
KAVRHVGTAREALIGSWLCNASEAWNWPVATHVQDPLSLRMVAQVFGAVIENLLSTGHKI
LAATGRSDDNPVVVEGRVMTSGGSLPLDVTILLESAALCMAHAARNAFNRCVILGNGQRR
DLPVNLVPPGRIATGFGPIIKLAGEIFSRVLSMSNPVSAQSLVVAAGLEDEAAFLPLVIE
RFERQMRALRRLAALEALLSAQAIDILGDEPQGVAKMIYDLVRSHAAFYTVDRPLSAEVE
AIEEELGSDAFISKLIGEVPIASFDDFFALGSLERIEERLASEPMVL