Protein Info for ABIE40_RS00125 in Rhizobium sp. OAE497

Annotation: mannitol dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01232: Mannitol_dh
  • amino acids 28 to 188 (161 residues), 110.5 bits, E=9.2e-36
• PF08125: Mannitol_dh_C
  • amino acids 217 to 431 (215 residues), 245.9 bits, E=4.5e-77

Best Hits

KEGG orthology group: K00040, fructuronate reductase [EC: 1.1.1.57] (inferred from 84% identity to rlt:Rleg2_4022)

Predicted SEED Role

"D-mannonate oxidoreductase (EC 1.1.1.57)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.57)

MetaCyc Pathways

• D-fructuronate degradation (4/4 steps found)
• superpathway of β-D-glucuronosides degradation (6/7 steps found)
• superpathway of hexuronide and hexuronate degradation (8/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (16/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.57

Protein Sequence (484 amino acids)

>ABIE40_RS00125 mannitol dehydrogenase family protein (Rhizobium sp. OAE497)
MSDRLKDLNGLAPTAKLPAYDRSKLKAGILHLGPGAFFRAHFAPFTDAALAATGGDWGIE
VASLRTPDVADNLTAQNGLYTMLIRDTSGTTAEVIGPILKAHVAPRDPALLLSRLEDPAI
RIVSLTVTEKAYGLDVRTGGLDLTHPDVAADLANRHAPRGVVGYLVEGLARRRAKGVAPF
TPLSCDNLPSNGAVLKRLVLEFAGRIDPELHAWIETNVPFPSTMVDRITPASTDATYADA
ERLTGQQDLAAIETEPFTQWVIEDHFANGRPDWDKAGVLMVDEVSAYEKMKLRMLNGAHS
LLAYLGYIGGYEYIRDVMDDEGLAALARRQMNAAAKTLDPVPGINLEHYADELIARFANK
AIAHRTYQIAMDGTQKLPQRLLEPATEALARGSQAETYAIAVAAWMRYALGVDRNGKAYE
LRDPRAEEIATLLADVPRNGGAVSAALFTLPGLFPKALTDNVVWTEDVANKLDILIQDNK
LPLF