Protein Info for ABID97_RS26205 in Variovorax sp. OAS795

Annotation: molybdopterin cofactor-binding domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 729 transmembrane" amino acids 27 to 48 (22 residues), see Phobius details PF02738: MoCoBD_1" amino acids 306 to 536 (231 residues), 88.5 bits, see alignment E=3.9e-29 PF20256: MoCoBD_2" amino acids 577 to 657 (81 residues), 43.3 bits, see alignment E=3.3e-15

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 96% identity to vap:Vapar_5484)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (729 amino acids)

>ABID97_RS26205 molybdopterin cofactor-binding domain-containing protein (Variovorax sp. OAS795)
MEHPESGAGPTPAPSHDEPPGMRRRDLLGYAASAPLISAAAGLGGLAAPSSARAAVLPMT
PPDTTDLIDIGDAVTVTALPTMPLVKVSGLANGRVRLELPRFESGQGIATAAAMMLADKL
GLPLNAIEVGSADASPELVFNQLTGGSSSVRSLHAGMPLLGGVGGLAGGSANPVVGRRVT
RLDALDIVTGRKKFTLDQAVPDAKPTMVCRPPTINGQFVRINNTTAVMGMPGVLGIAPIP
ATNGIVPTPPGVAVMAETFGQAWAAVNALDVTWTAGAVAAESNASIQQKLKSALLPFVLP
PLGALTVEGEFEFAAVSHCPMETECAIADVRADRAEVWSGLQSPIVTQQAVAADLGLPLD
RVKVHAVPSGGSFGRRLFWDATLQAVQISKALGRPCRLMYHRTDDMRHGRVRPPMFHRAR
ATMLLGQVIAFEQRIAGVRLDTRHGFGEMLGAAAIALPNGFPQTVGNFAIEQAMFKTMVS
SPYNFGVTTKLLTPVAMDINTCSYRSVHIQPSRLVEEILVDEMARALRKDPVAFRLEYLR
LPRARAVLKAVAEAAQWGKAMPPGFAQGVGVHQESKSFTACIVEIDARVPADIKVTRATI
AIDVGTPINPSGIEAQMQGGLCESISIVLTAGLHIQNGLPLEGSYSQYHFARMKNYPKDV
KVIIMPATSGEAIGGLGEVGLSASSGAIANAYARATGKKPRSFPLNFPVDFTPIPPGKLP
TPVTVPVPA