Protein Info for ABID97_RS25635 in Variovorax sp. OAS795

Annotation: nickel-responsive transcriptional regulator NikR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 160 PF01402: RHH_1" amino acids 3 to 41 (39 residues), 31.3 bits, see alignment E=1.4e-11 PF08753: NikR_C" amino acids 58 to 133 (76 residues), 64.2 bits, see alignment E=1e-21

Best Hits

Swiss-Prot: 40% identical to NIKR_PSEPK: Putative nickel-responsive regulator (PP_3341) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K07722, CopG family transcriptional regulator, nickel-responsive regulator (inferred from 85% identity to vpe:Varpa_4605)

Predicted SEED Role

"Nickel responsive regulator NikR" in subsystem Transport of Nickel and Cobalt

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (160 amino acids)

>ABID97_RS25635 nickel-responsive transcriptional regulator NikR (Variovorax sp. OAS795)
MNRFTISLDEQLARQFEMLIAQKRYTSRSEAVRDLIRYGLGRAGLRGMQFDAVVSSCIAS
VSYVYDTREGALVTRLQALRHAHHGMVTACNQTPLDLGSCLECVVLRGSIAAVHDVADQL
MSMRGVRHGQANVVALTDGAAMPAHAHPPVPTHSHLTPLN